ReviewEClinicalMedicine2024
Pubertal hormones and mental health problems in children and adolescents: a systematic review of population-based studies.
Review in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Puberty-Promoting Treatment and Psychosocial Well-Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial.Clinical endocrinology · 2026Trial
- Association between menstrual cycle characteristics and mental health in early adolescence.European child & adolescent psychiatry · 2026Article
- Shared Behavioural Determinants of Short Sleep and Obesity From Childhood to Adolescence: An Analyses of Growing Up in Scotland Birth Cohort 1.Pediatric obesity · 2026Observational
- [Research progress on influencing factors and biological mechanisms of non-suicidal self-injury in children and adolescents].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Emotional and Behavioural Problems Including Anxiety and Depressive Symptoms Across Tanner Stages in Girls With Central Precocious Puberty: A Retrospective Clinical Study.Actas espanolas de psiquiatria · 2026Article
- The sex-specific role of adrenal androgens in youth psychopathology.Translational psychiatry · 2026Article
- Comparative Trends in the Burden of Depressive Disorders in China and Globally, 1990-2021: Evidence From the Global Burden of Disease 2021.Alpha psychiatry · 2026Article
- Links between hormonal and pubertal development, and adolescent females' risk for affective symptoms.Psychoneuroendocrinology · 2026Article
- Effectiveness and Safety of Hormonal Treatments in Children with Growth Disorders: A Systematic Review of Clinical Evidence.Clinics and practice · 2026Review
- Exploring Trajectories of Anxiety Symptoms in Autistic and Non-Autistic Youth over Adolescence Using Parent- and Self-Report Measures.Research in autism · 2026Article
- Early Pubertal Development Is a Risk Factor for Psychotic-Like Experiences in Boys and Girls.Biological psychiatry global open science · 2026Article
- The association between age at menarche and subsequent risk of chronic pain.Frontiers in global women's health · 2026Review
- Article
- Secular trends in age at menarche among Han Chinese females in Shanghai: a large-scale community-based study.BMC women's health · 2025Article
- Anxiety and Depression in Adolescents with Prelingual Hearing Loss: Prevalence and Risk Factors.Journal of clinical medicine · 2025Article
- Mental toughness and gender differences in adolescent depression: development of a predictive nomogram for early identification.BMC psychology · 2025Article
- Genetic, neuropeptidergic, and cardiometabolic interplay in female central precocious puberty.Cardiovascular endocrinology & metabolism · 2025Review
- Trajectories of childhood eating behaviors and their association with internalizing and externalizing symptoms in adolescence.BMC pediatrics · 2025Article
- Prevalence and associated factors of emotional and behavioral problems in Indonesian early adolescents: A cross-sectional study.Belitung nursing journal · 2025Article
- Network analysis of the relationship between negative life events and depressive symptoms among adolescents: a comparison between males and females.Frontiers in pediatrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the increased prevalence of mental health problems during adolescence, there is considerable interest in understanding potential biological mechanisms including the contribution of pubertal hormones. This systematic review of 55 papers aimed to synthesize the evidence for the effect of pubertal hormones on the risk for mental health problems in children and adolescents. The pattern of findings from included studies suggested associations of testosterone and estradiol with certain types of mental health problems, but with inconsistencies relating to DHEA and DHEA-S. However, the state of evidence for the causal effects of hormones was determined to be weak given assessment of bias from confounding, hormone measurement error, selection bias and missingness. Further investigations with careful consideration of study design and analysis, particularly accounting for short-term variation of hormone levels and appropriate selection of confounders, is necessary to advance our understanding of hormonal effects on mental health. Such efforts will improve knowledge of risk mechanisms, and may support the development of targeted intervention efforts for mental health problems.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.