Evidence mapPaperPMID 39404384Full record

ReviewCells2024

The Role of Non-Coding RNAs in Regulating Cachexia Muscle Atrophy.

Guoming Chen, Jiayi Zou, Qianhua He, Shuyi Xia, Qili Xiao, Ruoxi Du, Shengmei Zhou, Cheng Zhang, Ning Wang, Yibin Feng

Abstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guoming ChenSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Jiayi ZouFirst Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Qianhua HeFirst Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Shuyi XiaFifth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Qili XiaoSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Ruoxi DuEighth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Shengmei ZhouSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Cheng ZhangSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Ning WangSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Yibin FengSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Funding

Enhanced new staff start-up fund 204610519Health and Medical Research Fund 15162961, 16172751 and 18192141Pre-emptive retention fund 202007002the Gaia Family Trust of New Zealand 200007008the Research Council of the University of Hong Kong 104004092 and 104004460the Research Grants Committee (RGC) of Hong Kong, HKSAR 740608, 766211, 17152116 and 17121419
6 · The paper itself

Abstract

Cachexia is a late consequence of various diseases that is characterized by systemic muscle loss, with or without fat loss, leading to significant mortality. Multiple signaling pathways and molecules that increase catabolism, decrease anabolism, and interfere with muscle regeneration are activated. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play vital roles in cachexia muscle atrophy. This review mainly provides the mechanisms of specific ncRNAs to regulate muscle loss during cachexia and discusses the role of ncRNAs in cachectic biomarkers and novel therapeutic strategies that could offer new insights for clinical practice.

Indexed as

CachexiaMuscular AtrophyRNA, UntranslatedAnimalsBiomarkersHumansMicroRNAsMuscle, SkeletalRNA, CircularRNA, Long NoncodingBiomarkersMicroRNAsRNA, CircularRNA, Long NoncodingRNA, UntranslatedcachexiacircRNAslncRNAsmicroRNAsmuscle atrophynon-coding RNAs

Identifiers

PMID39404384
PMCPMC11482569

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.