Evidence map›Paper›PMID 39404398›Full record

ArticleCells2024

Pulmonary and Systemic Immune Profiles Following Lung Volume Reduction Surgery and Allogeneic Mesenchymal Stromal Cell Treatment in Emphysema.

Li Jia, Na Li, Vincent van Unen, Jaap-Jan Zwaginga, Jerry Braun, Pieter S Hiemstra, Frits Koning, P Padmini S J Khedoe, Jan Stolk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li JiaDepartment of Immunology, Leiden University Medical Center (LUMC), 2333 Leiden, The Netherlands.
Na LiDepartment of Immunology, Leiden University Medical Center (LUMC), 2333 Leiden, The Netherlands.
Vincent van UnenDepartment of Immunology, Leiden University Medical Center (LUMC), 2333 Leiden, The Netherlands.ORCID 0000-0001-9339-8430
Jaap-Jan ZwagingaDepartment of Hematology, Leiden University Medical Center, 2333 Leiden, The Netherlands.ORCID 0000-0003-1228-7769
Jerry BraunDepartment of Cardiothoracic Surgery, Leiden University Medical Center, 2333 Leiden, The Netherlands.ORCID 0000-0002-4504-6235
Pieter S HiemstraDepartment of Pulmonology, PulmoScience Lab, Leiden University Medical Center (LUMC), 2333 Leiden, The Netherlands.ORCID 0000-0002-0238-5982
Frits KoningDepartment of Immunology, Leiden University Medical Center (LUMC), 2333 Leiden, The Netherlands.
P Padmini S J KhedoeDepartment of Pulmonology, PulmoScience Lab, Leiden University Medical Center (LUMC), 2333 Leiden, The Netherlands.ORCID 0000-0002-0798-014X
Jan StolkDepartment of Pulmonology, PulmoScience Lab, Leiden University Medical Center (LUMC), 2333 Leiden, The Netherlands.

Funding

Chinese Scholarship council 201906170073Netherlands Organisation for Health Research and Development 0414009816007)
6 · The paper itself

Abstract

Emphysema in patients with chronic obstructive pulmonary disease (COPD) is characterized by progressive inflammation. Preclinical studies suggest that lung volume reduction surgery (LVRS) and mesenchymal stromal cell (MSC) treatment dampen inflammation. We investigated the effects of bone marrow-derived MSC (BM-MSC) and LVRS on circulating and pulmonary immune cell profiles in emphysema patients using mass cytometry. Blood and resected lung tissue were collected at the first LVRS (L1). Following 6-10 weeks of recovery, patients received a placebo or intravenous administration of 2 × 10

Indexed as

LungMesenchymal Stem CellsMesenchymal Stem Cell TransplantationPulmonary EmphysemaAgedFemaleHumansMaleMiddle AgedPneumonectomyTransplantation, Homologousbone marrow-derived mesenchymal stromal cells (BM-MSCs)emphysemalung volume reduction surgery (LVRS)mass cytometry by-time-of-flight (CyTOF)pulmonary immune profilesystemic immune profile

Identifiers

PMID39404398
PMCPMC11476308

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.