Evidence map›Paper›PMID 39404973›Full record

ArticleEuropean journal of epidemiology2024

Associations of coagulation parameters and thrombin generation potential with the incidence of type 2 diabetes: mediating role of glycoprotein acetylation.

Jihee Han, Astrid van Hylckama Vlieg, Renée de Mutsert, Frits R Rosendaal, Jeroen Hpm van der Velde, Sebastiaan C Boone, Esther Winters-van Eekelen, Saskia le Cessie, Ruifang Li-Gao

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Article in European journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jihee HanDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands.
Astrid van Hylckama VliegDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands.
Renée de MutsertDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands.
Frits R RosendaalDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands.
Jeroen Hpm van der VeldeDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands.
Sebastiaan C BooneDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands.
Esther Winters-van EekelenDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands.
Saskia le CessieDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands.
Ruifang Li-GaoDepartment of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands. r.li@lumc.nl.

Funding

Stichting De Merel Stichting De Merel
6 · The paper itself

Abstract

Hypercoagulability is characterized by abnormal elevations of coagulation factor levels and increased thrombin generation potential. Prior studies demonstrated links between impaired glucose metabolism, endothelial dysfunction, and hypercoagulability. However, the associations between hypercoagulability and incident type 2 diabetes as well as its underlying mechanism remain unclear. We aimed to assess the associations between coagulation parameters including coagulation factor (F) VIII, FIX, FXI, fibrinogen, thrombin generation potential (lag time, endogenous thrombin potential [ETP], peak, time-to-peak, velocity) and incident type 2 diabetes, and to study the underlying mechanism by examining the mediating role of glycoprotein acetylation (GlycA). In the Netherlands Epidemiology of Obesity study, we applied a Cox Proportional-Hazards Model in 5718 participants after adjustment for confounders. We further conducted a mediation analysis investigating the mediation effect of GlycA on the observed associations. During a median follow-up of 6.7 years, 281 incident type 2 diabetes diagnoses were reported. Compared with the lowest quartile, hazard ratio (95% confidence interval) of the highest quartile was 2.47 (1.48-4.14) for FIX, 1.37 (0.85-2.20) for FVIII, 1.11 (0.76-1.63) for FXI, 0.98 (0.65-1.48) for fibrinogen, 1.56 (1.07-2.28) for ETP, 1.84 (1.23-2.74) for peak, 1.59 (1.08-2.33) for velocity, 0.92 (0.62-1.38) for lag time, and 1.21 (0.86-1.70) for time-to-peak. GlycA mediated only a small proportion of all observed associations. In conclusion, elevated levels of coagulation factor and thrombin generation potential are associated with incident type 2 diabetes, suggesting the involvement of hypercoagulability in the pathogenesis of type 2 diabetes.

Indexed as

Blood CoagulationDiabetes Mellitus, Type 2ThrombinAcetylationAdultAgedBlood Coagulation FactorsFemaleGlycoproteinsHumansIncidenceMaleMiddle AgedNetherlandsProportional Hazards ModelsThrombophiliaBlood Coagulation FactorsGlycoproteinsThrombinCoagulation factorEpidemiologyGlycoprotein acetylationMediation analysisThrombin generation potentialType 2 diabetes

Identifiers

PMID39404973
PMCPMC11599431

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.