Evidence map›Paper›PMID 39405519›Full record

ArticleAnalytical chemistry2024

Microfluidic-Integrated Chip Resonators for Electron Spin Sensing in Submicromolar, Submicroliter Solutions.

Nandita Abhyankar, Megan A Catterton, Gregory A Cooksey, Veronika A Szalai

Abstract read
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nandita AbhyankarInstitute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0002-1991-2160
Megan A CattertonDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States.
Gregory A CookseyNational Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States.ORCID 0000-0003-0200-2715
Veronika A SzalaiNational Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States.ORCID 0000-0002-1115-2849

Funding

Highly Sensitive Planar Anapole Microresonators for Electron Paramagnetic Resonance Spectroscopy of Submicroliter/Submicromolar SamplesR21GM134406 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI ROBINSON, PHYLLIS R · 2020 to 2021
$376k
Intramural NIST DOC 9999-NISTNIGMS NIH HHS R21 GM134406
6 · The paper itself

Abstract

Planar or chip microresonators decrease the sample volume required for magnetic resonance spectroscopies to the nanoliter scale. However, the interrogation of nanoliter-scale solution samples on planar sensors is hindered by the lack of microfluidic devices that can simultaneously provide a small total volume and long-term sample stability. Here, we report microfluidic devices that decrease the total required sample volume to the submicroliter scale and also provide long-term physical stability and storability. We also report a 3D-printed microfluidic with a self-contained actuation mechanism, which allows the sample to be retracted from the microresonator surface for storage. The microfluidic devices are fabricated easily by laser cutting or 3D printing and are integrable with a broad range of planar sensors. We use planar inverse anapole (PIA) microresonators to obtain continuous wave (CW) electron paramagnetic resonance (EPR) spectra of natural-isotopic-abundance nitroxide radicals, which are ubiquitously used as reporters of biomolecular dynamics. We provide experimental evidence for a concentration sensitivity of 330 ± 40 nmol L

Identifiers

PMID39405519
PMCPMC11555861

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.