Evidence map›Paper›PMID 39405525›Full record

SynthesisJMIR medical informatics2024

Application of Spatial Analysis on Electronic Health Records to Characterize Patient Phenotypes: Systematic Review.

Abolfazl Mollalo, Bashir Hamidi, Leslie A Lenert, Alexander V Alekseyenko

Abstract readSystematic Review
In one paragraph

Synthesis in JMIR medical informatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Abolfazl MollaloBiomedical Informatics Center, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States.ORCID 0000-0001-5092-0698
Bashir HamidiBiomedical Informatics Center, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States.ORCID 0000-0002-4559-299X
Leslie A LenertBiomedical Informatics Center, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States.ORCID 0000-0002-9680-5094
Alexander V AlekseyenkoBiomedical Informatics Center, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States.ORCID 0000-0002-5748-2085

Funding

South Carolina Cancer Disparities Research Center (SC CADRE)U54CA210962 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TURNER, DAVID PAUL · 2017 to 2023
$6.7M
SC Biomedical Informatics & Data Science for Health Impact (SC BIDS4Health)T15LM013977 · NLM · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Alexander V Alekseyenko, Brian Dean · 2022 to 2026
$1.2M
NCI NIH HHS U54 CA210962NLM NIH HHS T15 LM013977
6 · The paper itself

Abstract

backgroundElectronic health records (EHRs) commonly contain patient addresses that provide valuable data for geocoding and spatial analysis, enabling more comprehensive descriptions of individual patients for clinical purposes. Despite the widespread use of EHRs in clinical decision support and interventions, no systematic review has examined the extent to which spatial analysis is used to characterize patient phenotypes.

objectiveThis study reviews advanced spatial analyses that used individual-level health data from EHRs within the United States to characterize patient phenotypes.

methodsWe systematically evaluated English-language, peer-reviewed studies from the PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar databases from inception to August 20, 2023, without imposing constraints on study design or specific health domains.

resultsA substantial proportion of studies (>85%) were limited to geocoding or basic mapping without implementing advanced spatial statistical analysis, leaving only 49 studies that met the eligibility criteria. These studies used diverse spatial methods, with a predominant focus on clustering techniques, while spatiotemporal analysis (frequentist and Bayesian) and modeling were less common. A noteworthy surge (n=42, 86%) in publications was observed after 2017. The publications investigated a variety of adult and pediatric clinical areas, including infectious disease, endocrinology, and cardiology, using phenotypes defined over a range of data domains such as demographics, diagnoses, and visits. The primary health outcomes investigated were asthma, hypertension, and diabetes. Notably, patient phenotypes involving genomics, imaging, and notes were limited.

conclusionsThis review underscores the growing interest in spatial analysis of EHR-derived data and highlights knowledge gaps in clinical health, phenotype domains, and spatial methodologies. We suggest that future research should focus on addressing these gaps and harnessing spatial analysis to enhance individual patient contexts and clinical decision support.

Indexed as

Electronic Health RecordsPhenotypeSpatial AnalysisHumansUnited Statesclinical phenotypeselectronic health recordsgeocodinggeographic information systemspatient phenotypesspatial analysis

Identifiers

PMID39405525
PMCPMC11522649

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.