ArticleNature genetics2024
A genome-wide association analysis reveals new pathogenic pathways in gout.
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Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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50citing papers in PubMed, 1 pooled it
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis.Frontiers in immunology · 2026Pooled it
- Deciphering the interplay between serum urate and bone mineral density: insights from observational and genetic perspectives.Journal of the International Society of Sports Nutrition · 2026Article
- NINJ1: implications for plasma membrane rupture and disease.Biochemical Society transactions · 2026Review
- Uric acid and subclinical atherosclerosis: distinct associations across coronary and carotid arteries.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Dietary Diversity and Risk of Developing Gout: A Cohort Study of 161,213 Participants.Arthritis care & research · 2026Article
- Stigma, lost autonomy, reclaimed identity, and uncertainty around safe movement: a qualitative interview study of physical activity in gout.Rheumatology international · 2026Article
- Loneliness, traditional risk factor control, genetic predisposition, and development of musculoskeletal disorders.Rheumatology (Oxford, England) · 2026Article
- Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout.Arthritis care & research · 2026Article
- Exploratory study of DEFB1 genetic variants and human β-defensin-1 expression in monosodium urate crystal-induced arthritis: insights into innate immune regulation.Molecular biology reports · 2026Article
- Oral supplementation ofApplied and environmental microbiology · 2026Article
- SLC52A1 is a neofunctionalized primate urate transporter enabling intestinal urate secretion.The Journal of biological chemistry · 2026Article
- A prospective study on the regulation of osteoarthritis risk through inflammatory pathways in clonal hematopoiesis.GeroScience · 2026Article
- Advances in the management of gout: From current strategies to emerging therapies.The Journal of international medical research · 2026Review
- Phagocytosis of Primary Human Macrophages is Elevated by Ex Vivo Supplementation with n-3 PUFA.Molecular nutrition & food research · 2026Article
- Is Gout an Autoinflammatory Disease?Current rheumatology reports · 2026Review
- Airborne particulate matter enhances with monosodium urate crystals the secretion of IL-1β by human immune cells.medRxiv : the preprint server for health sciences · 2026Article
- Leveraging ancestral recombination graphs for scalable mixed-model analysis of complex traits.Cell genomics · 2026Article
- Article
- The gut-joint axis in gout: microbial outer membrane vesicles and mFrontiers in immunology · 2026Review
- Plant-based diet, metabolic signature, genetic susceptibility, and risk of musculoskeletal disorders: a large-scale population-based prospective cohort study.Frontiers in public health · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
103 authors.
Tanya J Major *Department of Biochemistry, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-1955-0219
Riku Takei *Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-1243-2535
Hirotaka Matsuo *Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
Megan P Leask *Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nicholas A Sumpter *Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Ruth K Topless *Department of Biochemistry, University of Otago, Dunedin, New Zealand.
Yuya Shirai *Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID http://orcid.org/0000-0002-0518-9020
Wei Wang *Genomics R&D, 23andMe, Inc, Sunnyvale, CA, USA.ORCID http://orcid.org/0000-0001-5774-5941
Murray J CadzowDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-2299-4136
Amanda J Phipps-GreenDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-1763-9623
Zhiqiang LiThe Biomedical Sciences Institute and The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.ORCID http://orcid.org/0000-0002-0174-9254
Aichang JiShandong Provincial Key Laboratory of Metabolic Diseases, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Marilyn E MerrimanDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Emily MoriceDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Eric E KelleyDepartment of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.
Wen-Hua WeiDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Sally P A McCormickDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Matthew J BixleyDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Richard J ReynoldsDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kenneth G SaagDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Tayaza FadasonLiggins Institute, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-1170-7883
Evgenia GolovinaLiggins Institute, University of Auckland, Auckland, New Zealand.
Justin M O'SullivanLiggins Institute, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0003-2927-450X
Lisa K StampDepartment of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.ORCID http://orcid.org/0000-0003-0138-2912
Nicola DalbethDepartment of Medicine, University of Auckland, Auckland, New Zealand.
Abhishek AbhishekAcademic Rheumatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Michael DohertyAcademic Rheumatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID http://orcid.org/0000-0002-5763-8326
Edward RoddySchool of Medicine, Keele University, Keele, Staffordshire, United Kingdom.
Lennart T H JacobssonDepartment of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Meliha C KapetanovicDepartment of Clinical Sciences Lund, Section of Rheumatology, Lund University and Skåne University Hospital, Lund, Sweden.ORCID http://orcid.org/0000-0002-7853-514X
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Mariano AndrésRheumatology Department, Dr Balmis General University Hospital-ISABIAL, Alicante, Spain.ORCID http://orcid.org/0000-0002-0219-9055
Fernando Pérez-RuizOsakidetza, OSI-EE-Cruces, BIOBizkaia Health Research Institute and Medicine Department of Medicine and Nursery School, University of the Basque Country, Biskay, Spain.ORCID http://orcid.org/0000-0002-5268-1894
Rosa J TorresDepartment of Biochemistry, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain.ORCID http://orcid.org/0000-0003-4438-8900
Timothy RadstakeDepartment of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands.
Timothy L JansenDepartment of Rheumatology, VieCuri Medical Centre, Venlo, The Netherlands.
Matthijs JanssenDepartment of Rheumatology, VieCuri Medical Centre, Venlo, The Netherlands.ORCID http://orcid.org/0000-0003-3700-6257
Leo A B JoostenDepartment of Internal Medicine and Radboud Institute of Molecular Life Science, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-6166-9830
Ruiqi LiuDepartment of Internal Medicine and Radboud Institute of Molecular Life Science, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-9663-1357
Orsolya I GaalDepartment of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Tania O CrişanDepartment of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Simona RednicDepartment of Rheumatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Cluj, Romania.
Fina KurreemanDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Tom W J HuizingaDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-7033-7520
René ToesDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-9618-6414
Frédéric LiotéRheumatology Department, Feel'Gout, GH Paris Saint Joseph, Paris, France.
Pascal RichetteRheumatology Department, INSERM U1132, BIOSCAR, University Paris Cité, Lariboisière Hospital, Paris, France.
Thomas BardinRheumatology Department, INSERM U1132, BIOSCAR, University Paris Cité, Lariboisière Hospital, Paris, France.
Hang Korng EaRheumatology Department, INSERM U1132, BIOSCAR, University Paris Cité, Lariboisière Hospital, Paris, France.ORCID http://orcid.org/0000-0002-2393-7475
Tristan PascartDepartment of Rheumatology, Hopital Saint-Philibert, Lille Catholic University, Lille, France.
Geraldine M McCarthyDepartment of Rheumatology, Mater Misericordiae University Hospital and School of Medicine, University College, Dublin, Ireland.
Laura HelbertDepartment of Rheumatology, Mater Misericordiae University Hospital and School of Medicine, University College, Dublin, Ireland.
Blanka StibůrkováDepartment of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.ORCID http://orcid.org/0000-0003-2465-1476
Anne-K TauscheDepartment of Rheumatology, University Clinic 'Carl Gustav Carus' at the Technical University, Dresden, Germany.
Till UhligCenter for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway.
Véronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID http://orcid.org/0000-0002-4991-3797
Thibaud S BoutinMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID http://orcid.org/0000-0002-9405-9550
Philip L RichesCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Stuart H RalstonCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2804-7586
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0198-5078
Thomas M MacDonaldMEMO Research, Division of Molecular and Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom.ORCID http://orcid.org/0000-0001-5189-6669
FAST Study Group
Akiyoshi NakayamaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.ORCID http://orcid.org/0000-0002-6654-0726
Tappei TakadaDepartment of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan.
Masahiro NakatochiPublic Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Aichi, Japan.ORCID http://orcid.org/0000-0002-1838-4837
Seiko ShimizuDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
Yusuke KawamuraDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Yu ToyodaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.ORCID http://orcid.org/0000-0002-7411-0531
Hirofumi NakaokaDepartment of Cancer Genome Research, Sasaki Institute, Sasaki Foundation, Tokyo, Japan.ORCID http://orcid.org/0000-0002-8454-1159
Ken YamamotoDepartment of Medical Biochemistry, Kurume University School of Medicine, Fukuoka, Japan.ORCID http://orcid.org/0000-0002-1531-9685
Keitaro MatsuoDivision of Cancer Epidemiology & Prevention, Aichi Cancer Center, Aichi, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Nariyoshi ShinomiyaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
Kimiyoshi IchidaDepartment of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5102-7516
Japan Gout Genomics Consortium
Chaeyoung LeeDepartment of Bioinformatics and Life Science, Soongsil University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-2940-1778
Asia Pacific Gout Consortium
Linda A BradburyInstitute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, Australia.
Matthew A BrownInstitute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, Australia.ORCID http://orcid.org/0000-0003-0538-8211
Philip C RobinsonSchool of Clinical Medicine, Faculty of Medicine, University of Queensland, Brisbane, Australia.
Russell R C BuchananDepartment of Rheumatology, Austin Hospital, Melbourne, Victoria, Australia.
Catherine L HillRheumatology Department, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Susan LesterRheumatology Department, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Malcolm D SmithFlinders University, Adelaide, South Australia, Australia.
Maureen RischmuellerRheumatology Department, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Hyon K ChoiDivision of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Eli A StahlInstitute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeff N MinerViscient Biosciences, 5752 Oberlin Dr., Suite 111, San Diego, CA, 92121, USA.
Daniel H SolomonDivision of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jing CuiDivision of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kathleen M GiacominiDepartment of Bioengineering and Therapeutic Sciences and Institute for Human Genetics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8041-5430
Deanna J BrackmanDepartment of Bioengineering and Therapeutic Sciences and Institute for Human Genetics, University of California, San Francisco, CA, USA.
Eric M JorgensonDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0002-5829-8191
GlobalGout Genetics Consortium
Hongbo LiuPenn / The Children's Hospital of Pennsylvania Kidney Innovation Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19101, USA.
Katalin SusztakPenn / The Children's Hospital of Pennsylvania Kidney Innovation Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19101, USA.ORCID http://orcid.org/0000-0002-1005-3726
23andMe Research Team
Suyash ShringarpureGenomics R&D, 23andMe, Inc, Sunnyvale, CA, USA.ORCID http://orcid.org/0000-0001-6464-2668
Alexander SoService of Rheumatology, Center Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Yukinori Okada *Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Changgui Li *Shandong Provincial Key Laboratory of Metabolic Diseases, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.ORCID http://orcid.org/0000-0002-4622-3731
Yongyong Shi *Affiliated Hospital of Qingdao University and Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China.ORCID http://orcid.org/0000-0003-1710-1505
Tony R MerrimanDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA. tony.merriman@otago.ac.nz.ORCID http://orcid.org/0000-0003-0844-8726
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genetically independent signals (149 previously unreported loci in urate and gout). An additional 65 loci with signals in urate (from a GWAS of 630,117 individuals) but not gout were identified. A prioritization scheme identified candidate genes in the inflammatory process of gout, including genes involved in epigenetic remodeling, cell osmolarity and regulation of NOD-like receptor protein 3 (NLRP3) inflammasome activity. Mendelian randomization analysis provided evidence for a causal role of clonal hematopoiesis of indeterminate potential in gout. Our study identifies candidate genes and molecular processes in the inflammatory pathogenesis of gout suitable for follow-up studies.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyGoutPolymorphism, Single NucleotideUric AcidHumansHyperuricemiaMaleMendelian Randomization AnalysisNLR Family, Pyrin Domain-Containing 3 ProteinNLR Family, Pyrin Domain-Containing 3 ProteinUric Acid
Identifiers
PMID
39406924What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.