Evidence mapPaperPMID 39407059Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

Effects of Thyroid Hormones on Cellular Development in Human Ovarian Granulosa Tumor Cells (KGN).

Yakun Yu, Yilin Yao, Yan Liu, Ying Sun, Haoyuan Feng, Nana Kong, Rui Chen, Mingqi Wu, Shuaitian Guo, Shen Tian and 1 more

Abstract read
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In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Role of TInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yakun YuCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China.
Yilin YaoCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China.
Yan LiuCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China.
Ying SunCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China.
Haoyuan FengCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China.
Nana KongCenter for Assisted Reproductive Medicine, Department of Obstetrics and Gynecology, the Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, People's Republic of China.
Rui ChenCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China.
Mingqi WuCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China.
Shuaitian GuoCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China.
Shen TianCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China. cnu_tianshen@sina.com.
Cheng ZhangCollege of Life Science, Capital Normal University, Beijing, 100048, People's Republic of China. chzhang2011@cnu.edu.cn.ORCID 0000-0003-2962-0839

Funding

National Natural Science Foundation of China Nos. 32171109
6 · The paper itself

Abstract

Ovarian cancer is a common malignant tumor in the female reproductive system, and Granulosa cell tumor (GCT) of the ovary is a rare type of ovarian cancer, which significantly threatens women's reproductive health. It has been reported that dysregulation of thyroid hormones (THs) may be closely related to the progression and prognosis of ovarian cancer. Moreover, THs regulate phosphorylation of signal transducer and activator of transcription (STAT3) and Octamer-binding transcription factor 4 (OCT4) expression. It has been reported that STAT3 and OCT4 play important roles in cellular development and tumorigenesis. However, the mechanisms by which THs affect the development of GCT are still remained unclear. To evaluate the effect of THs on human ovarian granulosa tumor cells (KGN), cells were treated with 3,5,3' -triiodothyronine (T

Indexed as

Granulosa Cell TumorOvarian NeoplasmsThyroid HormonesTriiodothyronineCell Line, TumorCell ProliferationCell SurvivalFemaleHumansOctamer Transcription Factor-3STAT3 Transcription FactorOctamer Transcription Factor-3POU5F1 protein, humanSTAT3 protein, humanSTAT3 Transcription FactorThyroid HormonesTriiodothyronineKGN cellsOCT4Ovarian cancerSTAT3T3TR

Identifiers

PMID39407059

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.