Evidence mapPaperPMID 39407515Full record

ArticleMolecules (Basel, Switzerland)2024

Application of UHPLC-QqQ-MS/MS Method for Quantification of Beta-Adrenergic Blocking Agents (β-Blockers) in Human Postmortem Specimens.

Paweł Szpot, Kaja Tusiewicz, Olga Wachełko, Marcin Zawadzki

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paweł SzpotDepartment of Forensic Medicine, Wroclaw Medical University, 4 J. Mikulicza-Radeckiego Street, 50345 Wroclaw, Poland.ORCID 0000-0002-5352-3492
Kaja TusiewiczDepartment of Forensic Medicine, Wroclaw Medical University, 4 J. Mikulicza-Radeckiego Street, 50345 Wroclaw, Poland.
Olga WachełkoInstitute of Toxicology Research, 45 Kasztanowa Street, 55093 Borowa, Poland.
Marcin ZawadzkiFaculty of Medicine, Department of Social Sciences and Infectious Diseases, Wroclaw University of Science and Technology, 27 Wybrzeże Wyspiańskiego, 50370 Wroclaw, Poland.ORCID 0000-0003-2146-9724

Funding

Wroclaw Medical University SUBK.A120.23.062
6 · The paper itself

Abstract

Betablockers are one of the most frequently used medications in cardiology. They can lead to fatal drops in blood pressure and heart rhythm disturbances. Death is functional, and poisoning with this group of drugs can be difficult to detect. The liquid-liquid extraction (LLE) method developed using ethyl acetate at pH 9 successfully identified 18 β-blockers in human blood. The method's limit of quantification (LOQ) was in the range of 0.1 to 0.5 ng/mL. No carryover of substances between samples was detected, and no interfering ion current signals were observed in the biological samples at the retention times of the compounds or internal standards. All compounds had a coefficient of determination (R

Indexed as

Adrenergic beta-AntagonistsLiquid-Liquid ExtractionTandem Mass SpectrometryAutopsyChromatography, High Pressure LiquidHumansLimit of DetectionReproducibility of ResultsAdrenergic beta-Antagonistsbeta-adrenergic receptor antagonistsbetablockersdrugs intoxicationforensic toxicologyUHPLC-QqQ-MS/MS

Identifiers

PMID39407515
PMCPMC11477679

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.