Evidence map›Paper›PMID 39408382›Full record

ArticleNutrients2024

The Mechanism Involved in the Inhibition of Resveratrol and Genistein on the Contractility of Isolated Rat Uterus Smooth Muscle.

Qin Ma, Yudong Wang, Wei Zhang, Zhongrui Du, Zhifeng Tian, Hongfang Li

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qin MaDepartment of Physiology, College of Basic Medicine, Lanzhou University, Lanzhou 730000, China.
Yudong WangSchool of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Wei ZhangDepartment of Physiology, College of Basic Medicine, Lanzhou University, Lanzhou 730000, China.
Zhongrui DuDepartment of Physiology, College of Basic Medicine, Lanzhou University, Lanzhou 730000, China.
Zhifeng TianFunction Laboratory in College of Basic Medicine, Lanzhou University, Lanzhou 730000, China.
Hongfang LiDepartment of Physiology, College of Basic Medicine, Lanzhou University, Lanzhou 730000, China.ORCID 0000-0002-0153-1394

Funding

the Natural Science Foundation of Gansu province in China 20JR5RA298
6 · The paper itself

Abstract

purposeThis study aimed to compare the effects of the phytoestrogens resveratrol (RES) and genistein (GEN) on the contractility of isolated uterine smooth muscle from rats, focusing on both spontaneous and stimulated contractions, and to investigate the underlying mechanisms.

methodsUterine strips were suspended vertically in perfusion chambers containing Kreb's solution, various concentrations of RES and GEN were added to the ex vivo uterine strips, and contractions were measured before and after incubation with RES or GEN.

results(1) Both RES and GEN inhibited K

conclusionsRES and GEN can directly inhibit both spontaneous and activated contractions of isolated uterine smooth muscle. The mechanisms underlying the inhibitory effects of RES and GEN likely involve β adrenergic receptor activation, reduced Ca

Indexed as

GenisteinResveratrolUterine ContractionAnimalsCalciumDinoprostDose-Response Relationship, DrugFemaleMuscle ContractionMuscle, SmoothPhytoestrogensRatsRats, Sprague-DawleyUterusCalciumDinoprostGenisteinPhytoestrogensResveratrolCa2+ influx and releasegenisteinresveratrolsmooth muscleuterine movement

Identifiers

PMID39408382
PMCPMC11478625

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.