ReviewPolymers2024
Manufacturing Process of Hyaluronic Acid Dermal Fillers.
Review in Polymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical Durability of Hyaluronic Acid-Based Dermal Fillers for Facial Application: A Systematic Review.Aesthetic plastic surgery · 2026Pooled it
- A Comparative Study of the Efficacy of Different Tissue Fillers for Nasolabial Fold Correction.Aesthetic plastic surgery · 2026Pooled it
- Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study.Aesthetic surgery journal · 2026Trial
- Bridging Scales: Integrating Hyaluronan-Based Nanoencapsulation into 3D Hydrogel Constructs for Advanced Therapeutics-A Comprehensive Review.Gels (Basel, Switzerland) · 2026Review
- Regenerative Functional Microspheres for Aesthetic Medicine: Mechanism, Materials, Fabrication, and Clinical Applications.Advanced healthcare materials · 2026Review
- Penetrating globe injury following periocular hyaluronic acid filler injection: A case report.American journal of ophthalmology case reports · 2026Article
- Hyaluronic Acid-Based Biomaterials in Tissue Engineering: From Molecular Properties to Re-Generative Applications.Journal of functional biomaterials · 2026Review
- Efficacy and safety of e.p.t.q. hyaluronic acid fillers in the context of aesthetic facial rejuvenation or beautification: a post-market clinical follow-up study.Scientific reports · 2026Article
- Comprehensive Analysis of Free BDPE Content in Commercial Hyaluronic Acid Fillers: Implications for Safety Assessment and Regulatory Standards.Journal of cosmetic dermatology · 2026Article
- The Safety Profile of a Portfolio of Hyaluronic Acid-Based Soft Tissue Fillers Manufactured Using MACRO Technology: A Systematic Review of Clinical Evidence.Life (Basel, Switzerland) · 2026Review
- Exploring the Immunological Implications of Insoluble Particulate Impurities in Hyaluronic Acid Fillers: Integrated Physicochemical and Histological Analyses of the Cohesive Polydensified Matrix Range.Clinical, cosmetic and investigational dermatology · 2026Article
- Hybrid Cooperative Complexes of Low- and High-Molecular-Weight Hyaluronic Acid in Aesthetic Medicine.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Residue-Based Thermogravimetric Analysis: A Novel Method to Quantify Carboxylate Group Modifications in Macromolecules.Biomacromolecules · 2025Article
- Evaluation of Bio-Stimulation Effects of Various Dermal Fillers: Hyaluronic Acid-Based Polynucleotides and Microparticle Fillers in Mouse Model.Aesthetic plastic surgery · 2025Article
- Modulating Rheological Properties via Non-Cross-Linked Phase in Biphasic Hyaluronic Acid Fillers.ACS omega · 2025Article
- Anatomical Considerations for Hyaluronic Acid Filler Injection for Breast Augmentation in Young Female Patients.Life (Basel, Switzerland) · 2025Article
- Analysis of Morphologic and Rheological Properties of Hyaluronic Acid Gel Fillers to Body Contouring and Its Clinical Correlation.Gels (Basel, Switzerland) · 2025Article
- Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review.Drugs in context · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid (HA) fillers are extensively utilized in aesthetic medicine due to their biocompatibility, reversibility, and effectiveness in enhancing skin hydration, volume, and overall appearance. These fillers are predominantly produced through microbial fermentation, followed by a critical cross-linking process that enhances their longevity by resisting enzymatic degradation. This review provides a thorough examination of the manufacturing processes that differentiate HA fillers, with particular attention to the distinctions between biphasic and monophasic variants. Unlike previous studies, this review emphasizes the specific cross-linking techniques and their substantial impact on the fillers' rheological properties, such as elasticity and cohesiveness, which are crucial to their clinical performance and patient outcomes. Additionally, the review offers a comprehensive comparison of HA fillers with non-HA alternatives, including calcium hydroxylapatite, poly-l-lactic acid, and polymethyl methacrylate, highlighting the unique advantages and potential complications associated with each type. By presenting novel insights into the latest advancements and challenges in filler technology, this review aims to provide clinicians with a deeper understanding of filler properties, thereby guiding them in making informed decisions to optimize patient safety and aesthetic results.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.