Evidence map›Paper›PMID 39408623›Full record

ArticleInternational journal of molecular sciences2024

DNA Damage in Moderate and Severe COVID-19 Cases: Relation to Demographic, Clinical, and Laboratory Parameters.

Tigran Harutyunyan, Anzhela Sargsyan, Lily Kalashyan, Naira Stepanyan, Rouben Aroutiounian, Thomas Liehr, Galina Hovhannisyan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tigran HarutyunyanLaboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University, Alex Manoogian 1, Yerevan 0025, Armenia.ORCID 0000-0002-1613-1019
Anzhela SargsyanLaboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University, Alex Manoogian 1, Yerevan 0025, Armenia.ORCID 0000-0003-2720-0355
Lily KalashyanLaboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University, Alex Manoogian 1, Yerevan 0025, Armenia.ORCID 0009-0004-0882-4984
Naira StepanyanNational Center for Infectious Diseases, Arno Babajanyan 21, Yerevan 0064, Armenia.ORCID 0009-0006-6506-3813
Rouben AroutiounianLaboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University, Alex Manoogian 1, Yerevan 0025, Armenia.ORCID 0000-0003-1020-9513
Thomas LiehrJena University Hospital, Institute of Human Genetics, Friedrich Schiller University, Am Klinikum 1, D-07747 Jena, Germany.ORCID 0000-0003-1672-3054
Galina HovhannisyanLaboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University, Alex Manoogian 1, Yerevan 0025, Armenia.ORCID 0000-0002-7450-1508

Funding

German Aerospace Center (Deutsches Forschungszentrum für Luft- und Raumfahrt, DLR) 01DK24003RA MESCS Science Committee 21AG-1F068RA MESCS Science Committee and German Federal Ministry of Education and Research 22SC-BMBF-1C001
6 · The paper itself

Abstract

The ability of the SARS-CoV-2 virus to cause DNA damage in infected humans requires its study as a potential indicator of COVID-19 progression. DNA damage was studied in leukocytes of 65 COVID-19 patients stratified by sex, age, and disease severity in relation to demographic, clinical, and laboratory parameters. In a combined group of COVID-19 patients, DNA damage was shown to be elevated compared to controls (12.44% vs. 5.09%,

Indexed as

COVID-19DNA DamageSARS-CoV-2Severity of Illness IndexAdultAgedAged, 80 and overAge FactorsC-Reactive ProteinCreatinineFemaleHumansInternational Normalized RatioLeukocytesMaleMiddle AgedC-Reactive ProteinCreatininecomet assayCOVID-19DNA damageSARS-CoV-2 virus

Identifiers

PMID39408623
PMCPMC11476890

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.