Evidence map›Paper›PMID 39408702›Full record

ArticleInternational journal of molecular sciences2024

Are BDNF and Stress Levels Related to Antidepressant Response?

Mónica Flores-Ramos, Andrés Vega-Rosas, Nadia Palomera-Garfias, Ricardo Saracco-Alvarez, Gerardo Bernabé Ramírez-Rodríguez

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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mónica Flores-RamosLaboratorio de Epidemiología Clínica, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City C.P. 14370, Mexico.ORCID 0000-0002-2798-7605
Andrés Vega-RosasLaboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City C.P. 14370, Mexico.ORCID 0000-0002-5000-7847
Nadia Palomera-GarfiasServicio Social, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón esq. Plan de San Luis S/N, Miguel Hidalgo, Casco de Santo Tomas, Mexico City C.P. 11340, Mexico.ORCID 0009-0004-5934-2360
Ricardo Saracco-AlvarezSubdirección de Investigación Clínica, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City, C.P. 14370, Mexico.
Gerardo Bernabé Ramírez-RodríguezLaboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City C.P. 14370, Mexico.ORCID 0000-0003-3243-1588

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnología (CONAHCYT) Grant Fronteras 2023 Number CF-2023-G-112 to MFR; Grant Infraestrutura, 2015, Number 254773 to GBRR
6 · The paper itself

Abstract

Antidepressant response is a multifactorial process related to biological and environmental factors, where brain-derived neurotrophic factor (BDNF) may play an important role in modulating depressive and anxious symptoms. We aimed to analyze how BDNF impacts antidepressant response, considering the levels of anxiety.

methodsA total of 40 depressed adults were included. We evaluated initial serum BDNF, anxiety through the State-Trait Anxiety Inventory (STAI), and the severity of depressive symptoms by the Hamilton Depression Rating Scale (HDRS). Participants received antidepressant treatment for 8 weeks, and response to treatment was evaluated according to the final HDRS scores.

resultsBasal BDNF was higher in responders compared to non-responder depressed patients, in addition to being inversely associated with the severity of anxiety and depression.

conclusionsBaseline BDNF serum is an adequate predictive factor for response to antidepressant treatment with SSRI, with lower pre-treatment levels of BDNF associated with higher anxiety symptoms after treatment. Stress levels could influence the response to treatment, but its association was not conclusive.

Indexed as

Antidepressive AgentsAnxietyBrain-Derived Neurotrophic FactorDepressionAdultFemaleHumansMaleMiddle AgedSelective Serotonin Reuptake InhibitorsStress, PsychologicalTreatment OutcomeAntidepressive AgentsBDNF protein, humanBrain-Derived Neurotrophic FactorSelective Serotonin Reuptake Inhibitorsantidepressant treatmentBDNFstate anxiety

Identifiers

PMID39408702
PMCPMC11476652

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.