Evidence mapPaperPMID 39408727Full record

ReviewInternational journal of molecular sciences2024

Low-Molecular-Weight Compounds Produced by the Intestinal Microbiota and Cardiovascular Disease.

Lorena Cuervo, Patrick L McAlpine, Carlos Olano, Javier Fernández, Felipe Lombó

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lorena CuervoResearch Group BIOMIC (Biosynthesis of Antitumor Molecules), Departamento de Biología Funcional, Área de Microbiología, Universidad de Oviedo, 33006 Oviedo, Spain.
Patrick L McAlpineIUOPA (Instituto Universitario de Oncología del Principado de Asturias), 33006 Oviedo, Spain.ORCID 0000-0002-9950-7156
Carlos OlanoResearch Group BIOMIC (Biosynthesis of Antitumor Molecules), Departamento de Biología Funcional, Área de Microbiología, Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0001-5440-3540
Javier FernándezIUOPA (Instituto Universitario de Oncología del Principado de Asturias), 33006 Oviedo, Spain.
Felipe LombóIUOPA (Instituto Universitario de Oncología del Principado de Asturias), 33006 Oviedo, Spain.ORCID 0000-0002-6680-6723

Funding

Asociación Española Contra el Cáncer PRDAS233973MCALCentro para el Desarrollo Tecnológico Industrial MIG-20201012Gobierno del Principado de Asturias AYUD/2021/51347Ministerio de Ciencia, Innovación y Universidades MCI-21-PID2020-113062RB-100Ministerio de Ciencia, Innovación y Universidades PID2021-127812OB-I00Ministerio de Ciencia, Innovación y Universidades PRE2019-089448
6 · The paper itself

Abstract

Cardiovascular disease is the main cause of mortality in industrialized countries, with over 500 million people affected worldwide. In this work, the roles of low-molecular-weight metabolites originating from the gut microbiome, such as short-chain fatty acids, hydrogen sulfide, trimethylamine, phenylacetic acid, secondary bile acids, indoles, different gases, neurotransmitters, vitamins, and complex lipids, are discussed in relation to their CVD-promoting or preventing activities. Molecules of mixed microbial and human hepatic origin, such as trimethylamine N-oxide and phenylacetylglutamine, are also presented. Finally, dietary agents with cardioprotective effects, such as probiotics, prebiotics, mono- and poly-unsaturated fatty acids, carotenoids, and polyphenols, are also discussed. A special emphasis is given to their gut microbiota-modulating properties.

Indexed as

Cardiovascular DiseasesGastrointestinal MicrobiomeAnimalsFatty Acids, VolatileHumansMolecular WeightPrebioticsProbioticsFatty Acids, VolatilePrebioticsbile acidshydrogen sulfidephenylacetylglutamineshort-chain fatty acidtrimethylamine N-oxide

Identifiers

PMID39408727
PMCPMC11477366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.