Evidence map›Paper›PMID 39409181›Full record

ArticleInternational journal of molecular sciences2024

Leonurine Inhibits Hepatic Lipid Synthesis to Ameliorate NAFLD via the ADRA1a/AMPK/SCD1 Axis.

Wen Fan, Maoxing Pan, Chuiyang Zheng, Haiyan Shen, Dajin Pi, Qingliang Song, Zheng Liang, Jianwei Zhen, Jinyue Pan, Lianghao Liu and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. ASIV Attenuates Cisplatin-Induced Proximal Tubular Injury by Enhancing Mitochondrial Biogenesis and Mitophagy Through the ADRA1A/AMPK/FOXO3A Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
  3. Review
  4. Jiangtang Decoction for Type 2 Diabetes and NAFLD: Integrative AnalysisEndocrine, metabolic & immune disorders drug targets · 2026
    Article
  5. Article
  6. Review
  7. International journal of molecular sciences · 2025
    Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wen FanSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Maoxing PanSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Chuiyang ZhengSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Haiyan ShenSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Dajin PiSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Qingliang SongSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Zheng LiangSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.ORCID 0009-0004-3488-2141
Jianwei ZhenSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Jinyue PanSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Lianghao LiuSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Qinhe YangSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Yupei ZhangSchool of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.ORCID 0000-0001-8837-1313

Funding

China Postdoctoral Science Foundation No. 2024M751135Fundamental Research Funds for the Central Universities, China No. 21624359Guangdong Basic and Applied Basic Research Foundation, China 2021A1515110774National Nature Science Foundation of China 82274393National Nature Science Foundation of China 82374230the Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization 2021B1212040007the Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine 202102010014the Natural Science Foundation of Guangdong Province, China 2021A1515012173the Natural Science Foundation of Guangdong Province, China 2022A1515011577the Science and Technology Innovation Research Program of Jinling Hospital 2023JCYJZD078the Traditional Chinese Medicine Bureau of Guangdong Province, China 20231085
6 · The paper itself

Abstract

Leonurine is a natural product unique to the Lamiaceae plant

Indexed as

AMP-Activated Protein KinasesGallic AcidLipid MetabolismLiverNon-alcoholic Fatty Liver DiseaseStearoyl-CoA DesaturaseAnimalsDiet, High-FatDisease Models, AnimalLipogenesisMaleMiceMice, Inbred C57BLSignal TransductionAMP-Activated Protein KinasesGallic AcidleonurineScd1 protein, mouseStearoyl-CoA DesaturaseADRA1a/AMPK/SCD1 axisleonurinelipid metabolismlipidomicnonalcoholic fatty liver diseasetranscriptomic

Identifiers

PMID39409181
PMCPMC11476755

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.