Evidence map›Paper›PMID 39410031›Full record

ArticleCancers2024

The Impact of Combined Chemotherapy and Intra-Tumoural Injection of Phosphorus-32 Microparticles on Vascularity in Locally Advanced Pancreatic Carcinoma.

Amanda Huoy Wen Lim, Joshua Zobel, Madison Bills, William Hsieh, Benjamin Crouch, Rohit Joshi, John-Edwin Thomson, EuLing Neo, Li Lian Kuan, Romina Safaeian and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Amanda Huoy Wen LimDepartment of Gastroenterology and Hepatology, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia.ORCID 0000-0001-8172-9140
Joshua ZobelDepartment of Gastroenterology and Hepatology, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia.
Madison BillsDepartment of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
William HsiehDepartment of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Benjamin CrouchDepartment of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Rohit JoshiMedical Oncology, Lyell McEwin Hospital, Adelaide, SA 5112, Australia.ORCID 0000-0003-4607-3937
John-Edwin ThomsonDepartment of Hepatobiliary Surgery, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
EuLing NeoDepartment of Hepatobiliary Surgery, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Li Lian KuanDepartment of Upper Gastrointestinal Surgery, Queen Elizabeth Hospital, Adelaide, SA 5011, Australia.
Romina SafaeianDepartment of Gastroenterology and Hepatology, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia.
Edmund TseDepartment of Gastroenterology and Hepatology, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia.ORCID 0000-0003-0643-3926
Christopher K RaynerDepartment of Gastroenterology and Hepatology, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia.
Andrew RuszkiewiczSchool Medicine, The University of Adelaide, Adelaide, SA 5005, Australia.
Nimit SinghalSchool Medicine, The University of Adelaide, Adelaide, SA 5005, Australia.ORCID 0009-0000-9379-445X
Dylan BartholomeuszDepartment of Gastroenterology and Hepatology, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia.
Nam Quoc NguyenDepartment of Gastroenterology and Hepatology, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor intra-tumoural vascularity contributes to a lack of response to chemotherapy in pancreatic cancers. Preliminary data suggest that the addition of endoscopic ultrasound (EUS)-guided intra-tumoural injection of phosphorus-32 (

methodsThis was a prospective single-centre trial from January 2022 to 2024 of patients with unresectable, non-metastatic LAPC undergoing standard FOLFIRINOX chemotherapy and

resultsA total of 20 patients underwent

conclusionThis is the first clinical study to demonstrate treatment-induced increased vascularity within pancreatic primary tumours, which followed

Indexed as

32 phosphorus microparticleschemotherapyintra-tumoural radiationpancreatic cancervascularity

Identifiers

PMID39410031
PMCPMC11475738

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.