Evidence map›Paper›PMID 39411949›Full record

ArticleCurrent medicinal chemistry2026

Synthesis of 2,4-bis(trifluoromethyl)benzaldehyde Hybrid Thiosemicarbazones as Prolyl Oligopeptidase Inhibitors for Neurodegenerative Disorders and their In silico Analysis.

Anam Rubbab Pasha, Saeed Ullah, Sobia Ahsan Halim, Ajmal Khan, Javid Hussain, Attalla F El-Kott, Muhammad Moazzam Naseer, Waleed Eltantawy, Ahmed Al-Harrasi, Zahid Shafiq

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Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Anam Rubbab PashaInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Saeed UllahNatural and Medical Sciences Research Center, University of Nizwa, Birkat-ul-Mouz 616, Nizwa, Sultanate of Oman.
Sobia Ahsan HalimNatural and Medical Sciences Research Center, University of Nizwa, Birkat-ul-Mouz 616, Nizwa, Sultanate of Oman.
Ajmal KhanNatural and Medical Sciences Research Center, University of Nizwa, Birkat-ul-Mouz 616, Nizwa, Sultanate of Oman.
Javid HussainDepartment of Biological Sciences and Chemistry, University of Nizwa, Nizwa-616, Sultanate of Oman.
Attalla F El-KottDepartment of Biology, College of Science, King Khalid University, Abha, Saudi Arabia.
Muhammad Moazzam NaseerDepartment of Chemistry, Quaid-i- Azam University, Islamabad, 45320, Pakistan.
Waleed EltantawyDepartment of Biology, Program of Preparatory Year, Batterjee Medical College, Aseer, 62451, Saudi Arabia.
Ahmed Al-HarrasiNatural and Medical Sciences Research Center, University of Nizwa, Birkat-ul-Mouz 616, Nizwa, Sultanate of Oman.
Zahid ShafiqInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.

Funding

Deanship of Scientific Research at King Khalid University RGP1/15/45
6 · The paper itself

Abstract

introductionProlyl-specific oligopeptidase (POP), one of the brain's highly expressed enzymes, is an important target for the therapy of central nervous system disorders, notably autism spectrum disorder, schizophrenia, Parkinson's, Alzheimer's disease, and dementia.

methodsThe current study was designed to investigate 2,4-bis(trifluoromethyl) benzaldehyde- based thiosemicarbazones as POP inhibitors to treat the above-mentioned disorders. A variety of techniques, such as nuclear magnetic resonance (NMR), mass spectrometry (MS), and Fourier-transform infrared spectroscopy (FTIR), were used for the structural confirmation of synthesized compounds. After

resultsCompound 3a emerged as the most active compound (IC

conclusionMoreover, molecular docking depicted a noticeable role of thiosemicarbazide moiety in the binding of these molecules within the active site of the POP enzyme.

Indexed as

BenzaldehydesNeurodegenerative DiseasesSerine EndopeptidasesSerine Proteinase InhibitorsThiosemicarbazonesHumansMolecular Docking SimulationMolecular StructureProlyl OligopeptidasesStructure-Activity RelationshipBenzaldehydesPREPL protein, humanProlyl OligopeptidasesSerine EndopeptidasesSerine Proteinase InhibitorsThiosemicarbazones24-bis(trifluoromethyl)benzaldehydekineticsmagnetic resonance.molecular dockingprolyl endo-peptidase inhibitorsthiosemicarbazone

Identifiers

PMID39411949

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.