Evidence map›Paper›PMID 39412669›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Inhibitory effects characteristics of polysaccharide of Polygonati Rhizome on cytochrome P450 enzymes.

Yan Duan, Xiaohong Wang, Ruidong Wang, Tian Zuo, Yue Du, Jian Zai, Lijun Zhu, Qi Zhan, Yao Fu

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yan Duan *College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Xiaohong Wang *Department of Pharmacy, Chongqing Public Health Medical Center, Chongqing, 400000, China.
Ruidong WangClinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, 200438, China.
Tian ZuoDepartment of Neurosurgery, Chang Zheng Hospital, Naval Medical University, Shanghai, 200003, China.
Yue DuDepartment of Pharmacy, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.
Jian ZaiDepartment of Intervention Radiology, Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, China.
Lijun ZhuDepartment of Intervention Radiology, Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, China.
Qi ZhanDepartment of Pharmacy, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China. Zhanqi_shjt@163.com.
Yao FuDepartment of Pharmacy, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. fuyao_1369@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAs the major active ingredient of Polygonatum sibriricum Red., polysaccharide of Polygonati Rhizome (PSP) has been reported to possess various pharmacological activities, especially for the treatment of chronic disorders in the elderly. This study evaluated the effect of PSP on the activities of major cytochrome P450 enzymes (CYP450) isoforms, aiming to provide theoretical reference for its co-prescription with other drugs and prevent the risk of adverse drug-drug interaction.

methodsThe activities of CYP450 isoforms were assessed in human liver microsomes with specific probe substances. Through Lineweaver-Burk fitting models, the effect of PSP on the activity of inhibited CYP450 isoforms was characterized by competitive and non-competitive models. Dose-dependent and time-dependent experiments were also performed to completely understand the inhibition.

resultsAmong experimental isoforms, PSP significantly inhibited the activities of CYP2C9, 2D6, and 3A4 in a concentration-dependent manner with IC

conclusionPSP exerted moderate inhibition on CYP2C9 and 2D6 and strong inhibition of CYP3A4. The dosage of CYP2C9-, 2D6-, and 3A4-metabolized drugs should be adjusted when co-administrated with PSP and its sourced herbs.

Indexed as

Cytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemPolygonatumPolysaccharidesCytochrome P-450 CYP2C9Cytochrome P-450 CYP3ADose-Response Relationship, DrugHumansMicrosomes, LiverRhizomeCYP2C9 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP2C9Cytochrome P-450 CYP3ACytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemPolysaccharidesCYP450Drug-drug interactionHuman liver microsomesProbe substanceTime-dependent inhibition

Identifiers

PMID39412669

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.