Evidence map›Paper›PMID 39414286›Full record

Trial reportBMJ open2024

Telephone lifestyle intervention to prevent diabetes in women with recent gestational diabetes mellitus attending the national health system: the LINDA-Brasil clinical trial.

Maria Inês Schmidt, Paula A Bracco, Maria A Nunes, Kadhija A Cherubini, Cristina D Castilhos, Jainara Z Spagiari, Leony M Galliano, Ruben Ladwig, Fabricio B Del Vecchio, Anelita H M Del Vecchio and 8 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02327286 (Prevenção do Diabetes em Mulheres Com Diabetes Gestacional prévio), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02327286 nacompletednot on this map

Prevenção do Diabetes em Mulheres Com Diabetes Gestacional prévio: Estudo multicêntrico de mudanças Intensivas de Estilo de Vida: LINDA-Brasil

TypeinterventionalSponsorFederal University of Rio Grande do SulRan2015 to 2022Enrolled473ConditionsDiabetes Mellitus, Diabetes, GestationalArmsPromote and support healthy behaviors
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Diabetes and women's health.Journal of diabetes investigation · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maria Inês SchmidtHospital de Clínicas de Porto Alegre, Porto Alegre, Brazil maria.schmidt@ufrgs.br.ORCID 0000-0002-3837-0731
Paula A BraccoPostgraduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Maria A NunesPostgraduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Kadhija A CherubiniPostgraduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Cristina D CastilhosHospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Jainara Z SpagiariPostgraduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Leony M GallianoGraduate Program in Physical Education, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Ruben LadwigPro-Rectory of Planning and Management-PROPLAN, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Fabricio B Del VecchioSuperior School of Physical Education, Federal University of Pelotas, Pelotas, Brazil.
Anelita H M Del VecchioSuperior School of Physical Education, Federal University of Pelotas, Pelotas, Brazil.
Michele DrehmerPostgraduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Adriana Costa FortiSchool of Medicine, Universidade Federal do Ceará, Fortaleza, Brazil.
Cristina FaçanhaIntegrated Center for Diabetes and Hypertension, Ceará State Health Department, Fortaleza, Brazil.
Lenita ZajdenvergUniversidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Bianca de Almeida-PitittoDepartment of Preventive Medicine, Escola Paulista de Medicina, Campus São, Brazil.
Rosângela Roginski RéaEndocrinology and Metabolism Service, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Patrícia Medici DualibDepartament of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Bruce B DuncanHospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate a postpartum telephone-based lifestyle intervention to prevent diabetes in high-risk women with recent gestational diabetes mellitus (GDM).

designMulticentre parallel randomised clinical trial.

settingSpecialised antenatal clinics in the Brazilian National System.

methodsLifestyle Intervention for Diabetes Prevention After Pregnancy compared (1:1) postpartum telephone support for lifestyle changes with conventional care in women with recent GDM at substantial risk for diabetes. Randomisation started on 28 March 2015 and ended on 13 March 2020, with the onset of the COVID-19 pandemic. We used Cox regression to estimate HRs for diabetes and analysis of covariance adjusted for follow-up time to assess weight change. OUTCOMES: The primary outcome was incident diabetes ascertained with blinded measurements of oral glucose tolerance tests. The secondary outcome was a change in measured weight.

resultsWe enrolled 5323 women with GDM, 2735 (51%) being at high risk. After invitations, baseline assessment and exclusions, we assigned 466 women to intervention (231) or control (235) groups. Attendance was satisfactory (≥7/20 phone sessions) in 75%. Over an average follow-up of 29.7 (15.6) months, 142 (30.5%) women progressed to diabetes, 75 (32%) in the control and 67 (29%) in the intervention group. There was no reduction in the incidence of diabetes (HR=0.84; 0.60-1.19) and only a non-significant 0.97 kg less weight gain (p=0.09). Among the 305 women randomised more than 1 year before the COVID-19 pandemic, the intervention did not reduce the incidence of diabetes (HR=0.71; 0.48-1.04) despite a 2.09 kg (p=0.002) lesser weight gain.

conclusionThe strategy to identify women with GDM at high risk proved valid, as women often gained weight and frequently developed diabetes. Over a 30-month follow-up, telephone support for lifestyle changes at postpartum did not reduce weight gain or diabetes incidence, although only 75% attended the minimum number of telephone sessions. The COVID-19 pandemic negatively impacted trial conduction. TRIAL REGISTRATION NUMBER: NCT02327286.

Indexed as

COVID-19Diabetes, GestationalTelephoneAdultBrazilDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestHumansLife StylePandemicsPostpartum PeriodPregnancySARS-CoV-2Weight GainClinical TrialGeneral diabetesObesity

Identifiers

PMID39414286
PMCPMC11481157

What Socratic holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.