Evidence map›Paper›PMID 39414727›Full record

ArticleMolecular neurobiology2025

Increased Levels of Circulating Methylglyoxal Have No Consequence for Cerebral Microvascular Integrity and Cognitive Function in Young Healthy Mice.

Eline Berends, Philippe Vangrieken, Naima Amiri, Marjo P H van de Waarenburg, Jean L J M Scheijen, Denise J H P Hermes, Kristiaan Wouters, Robert J van Oostenbrugge, Casper G Schalkwijk, Sébastien Foulquier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eline BerendsFaculty of Health Medicine and Life Sciences, Department of Internal Medicine, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0002-7115-001X
Philippe VangriekenFaculty of Health Medicine and Life Sciences, Department of Internal Medicine, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.
Naima AmiriFaculty of Health Medicine and Life Sciences, Department of Internal Medicine, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.
Marjo P H van de WaarenburgFaculty of Health Medicine and Life Sciences, Department of Internal Medicine, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.
Jean L J M ScheijenFaculty of Health Medicine and Life Sciences, Department of Internal Medicine, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.
Denise J H P HermesDepartment of Neuropsychology and Psychiatry, Maastricht University, Maastricht, the Netherlands.
Kristiaan WoutersFaculty of Health Medicine and Life Sciences, Department of Internal Medicine, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.
Robert J van OostenbruggeCARIM, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands.
Casper G Schalkwijk *Faculty of Health Medicine and Life Sciences, Department of Internal Medicine, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands. c.schalkwijk@maastrichtuniversity.nl.
Sébastien Foulquier *CARIM, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands. s.foulquier@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0002-2523-0748

Funding

European Foundation for the Study of Diabetes Research Programme in Microvascular Complications of Diabetes 2018
6 · The paper itself

Abstract

Diabetes and other age-related diseases are associated with an increased risk of cognitive impairment, but the underlying mechanisms remain poorly understood. Methylglyoxal (MGO), a by-product of glycolysis and a major precursor in the formation of advanced glycation end-products (AGEs), is increased in individuals with diabetes and other age-related diseases and is associated with microvascular dysfunction. We now investigated whether increased levels of circulating MGO can lead to cerebral microvascular dysfunction, blood-brain barrier (BBB) dysfunction, and cognitive impairment. Mice were supplemented or not with 50 mM MGO in drinking water for 13 weeks. Plasma and cortical MGO and MGO-derived AGEs were measured with UPLC-MS/MS. Peripheral and cerebral microvascular integrity and inflammation were investigated. Cerebral blood flow and neurovascular coupling were investigated with laser speckle contrast imaging, and cognitive tests were performed. We found a 2-fold increase in plasma MGO and an increase in MGO-derived AGEs in plasma and cortex. Increased plasma MGO did not lead to cerebral microvascular dysfunction, inflammation, or cognitive decline. This study shows that increased concentrations of plasma MGO are not associated with cerebral microvascular dysfunction and cognitive impairment in healthy mice. Future research should focus on the role of endogenously formed MGO in cognitive impairment.

Indexed as

Cerebrovascular CirculationCognitionMicrovesselsPyruvaldehydeAnimalsBlood-Brain BarrierCerebral CortexGlycation End Products, AdvancedMaleMiceMice, Inbred C57BLNeurovascular CouplingGlycation End Products, AdvancedPyruvaldehydeAdvanced glycation endproductsBlood–brain barrierCognitive functionGlyoxalase 1MethylglyoxalNeurovascular coupling

Identifiers

PMID39414727
PMCPMC11880179

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.