ArticleNature2024
A prenatal skin atlas reveals immune regulation of human skin morphogenesis.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
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Who cites it
49 citing papers in PubMed.
- Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro.Experimental & molecular medicine · 2026Article
- METTL1-mediated m7G modification regulates hair follicle cycle via the HOXC13/FOXN1/DSG4 axis.PLoS genetics · 2026Article
- Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota.Science advances · 2026Article
- Microglia and neuroinflammation: function, heterogeneity, and crosstalk.Cellular & molecular immunology · 2026Review
- Segmental specification of the human female fetal reproductive tract revealed by spatiotemporal dynamics.Nature cell biology · 2026Article
- Macrophages in embryonic development.Nature reviews. Immunology · 2026Review
- Pyroxylin shortens the resting stage of the hair cycle in mice.Scientific reports · 2026Article
- Dermal Microvascular Responses of Human Induced Pluripotent Stem Cell-Derived Skin Organoids to Inflammation and Injury.The American journal of pathology · 2026Article
- A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin.Experimental & molecular medicine · 2026Article
- Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine.ACS biomaterials science & engineering · 2026Article
- Generation and characterization of vestibular inner ear organoids from human pluripotent stem cells.Nature protocols · 2026Review
- Spatial architecture of development and disease.Nature reviews. Genetics · 2026Review
- 4D multimodal wound healing atlas reveals organ-level controls of repair phase transitions.bioRxiv : the preprint server for biology · 2026Article
- Cold Atmospheric Plasma-Activated In Situ Hydrogel Induces Hair Regeneration Via Immune Microenvironment Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immunomodulatory roles of regulatory T cells in cutaneous wound healing: mechanisms and therapeutic opportunities.Frontiers in immunology · 2026Review
- Deciphering the cellular landscape and genetic underpinnings of fiber diameter determined by dermal papilla cells in fine-wool sheep.Frontiers in cell and developmental biology · 2026Article
- Hair follicle organoids: advances in construction, applications, and translational challenges.Frontiers in cell and developmental biology · 2026Review
- Spatiotemporal decoding of skin biology: development, aging, disease, and regeneration.Burns & trauma · 2026Article
- CellScope: high-performance cell atlas workflow with tree-structured representation.Nature communications · 2025Article
- Pathophysiologic Mechanisms and Targeted Treatments Associated with the Nervous System in Cutaneous Allergic Diseases.Clinical reviews in allergy & immunology · 2025Review
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Authors and funding
71 authors.
Nusayhah Hudaa Gopee *Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-8507-5682
Elena Winheim *Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-0364-662X
Bayanne Olabi *Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Chloe AdmaneBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0009-0005-9327-9008
April Rose FosterWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-5397-4365
Ni HuangWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0001-8849-038X
Rachel A BottingBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Fereshteh TorabiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0009-0008-8660-3350
Dinithi SumanaweeraWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Anh Phuong LeDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0477-9969
Jin KimDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA.
Luca VergerKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID 0009-0007-9108-4711
Emily StephensonBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-4244-4019
Diana AdãoWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-6678-4923
Clarisse GanierCentre for Gene Therapy and Regenerative Medicine, King's College London Guy's Hospital, London, UK.
Kelly Y GimDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA.ORCID 0009-0003-5634-6836
Sara A SerdyDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA.
CiCi DeakinDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA.
Issac GohBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-6397-3518
Lloyd SteeleWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Karl AnnusverDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Mohi-Uddin MiahBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-5617-5350
Win Min TunBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Pejvak MoghimiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Kwasi Amoako KwakwaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Tong LiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-8240-4476
Daniela Basurto LozadaBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Ben RumneyWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Catherine L TudorWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0003-2093-9683
Kenny RobertsWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0001-6155-0821
Nana-Jane ChipampeWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-8802-0473
Keval SidhpuraBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Justin EnglebertBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Laura JardineBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Gary ReynoldsBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Antony RoseBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Vicky RoweWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Sophie PritchardWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Ilaria MulasWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0003-2556-9685
James FletcherBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Dorin-Mirel PopescuBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Elizabeth PoynerBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Anna DuboisDepartment of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Alyson GuyRare Skin Disease Laboratory, Synnovis, Guy's Hospital, London, UK.
Andrew FilbyBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Steven LisgoBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-5186-3971
Roger A BarkerDepartment of Clinical Neuroscience and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8843-7730
Ian A GlassDepartment of Pediatrics, Genetic Medicine, University of Washington, Seattle, WA, USA.
Jong-Eun ParkWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-1687-2423
Roser Vento-TormoWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-9870-8474
Marina Tsvetomilova NikolovaDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID 0000-0002-8212-049X
Peng HeWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
John E G LawrenceWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Josh MooreGerman BioImaging, Gesellschaft für Mikroskopie und Bildanalyse, Konstanz, Germany.ORCID 0000-0003-4028-811X
Stephane BallereauWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Christine B HaleWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0009-0000-8265-1082
Vijaya ShanmugiahWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
David HorsfallBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-8086-812X
Neil RajanBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-5850-5680
John A McGrathSt Johns Institute of Dermatology, King's College London Guy's Campus, London, UK.ORCID 0000-0002-3708-9964
Edel A O'TooleCentre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-4084-4836
Barbara TreutleinDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID 0000-0002-3299-5597
Omer BayraktarWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0001-6055-277X
Maria KasperDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6117-2717
Fränze ProgatzkyKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Pavel MazinWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0001-9268-3352
Jiyoon LeeDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-5561-5331
Laure GambardellaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0001-5771-1565
Karl R KoehlerDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA. Karl.Koehler@childrens.harvard.edu.ORCID 0000-0002-0685-538X
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. sat1003@cam.ac.uk.ORCID 0000-0002-6294-6366
Muzlifah HaniffaBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK. mh32@sanger.ac.uk.ORCID 0000-0002-3927-2084
Funding
LABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9MGeneration of human skin organoids from pluripotency (Admin Supplement)R01AR075018 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Karl Russell Koehler · 2019 to 2026
$3.6MEngineering self-assembled skin-on-a-chipR01AR083139 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Karl Russell Koehler · 2024 to 2026
$2.0MNIAMS NIH HHS R01 AR075018NIAMS NIH HHS R01 AR083139NICHD NIH HHS R24 HD000836Wellcome Trust
Abstract
Human prenatal skin is populated by innate immune cells, including macrophages, but whether they act solely in immunity or have additional functions in morphogenesis is unclear. Here we assembled a comprehensive multi-omics reference atlas of prenatal human skin (7-17 post-conception weeks), combining single-cell and spatial transcriptomics data, to characterize the microanatomical tissue niches of the skin. This atlas revealed that crosstalk between non-immune and immune cells underpins the formation of hair follicles, is implicated in scarless wound healing and is crucial for skin angiogenesis. We systematically compared a hair-bearing skin organoid (SkO) model derived from human embryonic stem cells and induced pluripotent stem cells to prenatal and adult skin
Indexed as
Hair FollicleMorphogenesisSingle-Cell AnalysisSkinWound HealingAdultAtlases as TopicEndothelial CellsFetusHuman Embryonic Stem CellsHumansImmunity, InnateInduced Pluripotent Stem CellsMacrophagesMultiomicsNeovascularization, Physiologic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.