Evidence map›Paper›PMID 39415004›Full record

ArticleNature2024

Glucose-sensitive insulin with attenuation of hypoglycaemia.

Thomas Hoeg-Jensen, Thomas Kruse, Christian L Brand, Jeppe Sturis, Christian Fledelius, Peter K Nielsen, Erica Nishimura, Alice R Madsen, Lennart Lykke, Kim S Halskov and 22 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. [Advances in injectable and transdermal glucose-responsive insulin delivery systems].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Smart closed-loop drug delivery systems.Nature reviews bioengineering · 2025
    Article
  17. Review
  18. A Synthetic Lectin for Glucuronate.ACS central science · 2025
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Thomas Hoeg-JensenGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0003-3882-6345
Thomas KruseGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0002-5756-753X
Christian L BrandGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0002-7355-4448
Jeppe SturisGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0001-9938-5278
Christian FledeliusGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.
Peter K NielsenGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.
Erica NishimuraGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0001-5741-3648
Alice R MadsenGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.ORCID 0009-0004-4624-7794
Lennart LykkeGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.
Kim S HalskovGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.
Simona KoščováAPIGENEX, Prague, Czech Republic.
Vladislav KotekAPIGENEX, Prague, Czech Republic.
Anthony P DavisUniversity of Bristol, Bristol, UK.ORCID 0000-0001-5213-624X
Robert A TromansCarbometrics, Bristol, UK.ORCID 0009-0008-8894-6963
Michael TomsettCarbometrics, Bristol, UK.ORCID 0009-0009-3246-4540
Guillem Peñuelas-HaroCarbometrics, Bristol, UK.
Daniel J LeonardCarbometrics, Bristol, UK.ORCID 0000-0003-2503-0890
Michael G OrchardCarbometrics, Bristol, UK.
Andy ChapmanCarbometrics, Bristol, UK.
Gaetano InvernizziGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.
Eva JohanssonGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0001-9330-5169
Daniele GranataDigital Science and Innovation, Novo Nordisk, Bagsværd, Denmark.
Bo F HansenGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.
Thomas A PedersenGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.
Jonas KildegaardGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.
Karen-Margrethe PedersenGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.ORCID 0009-0004-0386-2391
Hanne H F RefsgaardGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0002-4996-4084
Lene AlifrangisGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0002-5356-6484
Johannes J FelsGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.ORCID 0000-0002-6616-6746
Anita V Neutzsky-WulffGlobal Research Technologies, Novo Nordisk, Bagsværd, Denmark.
Per SauerbergGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark.
Rita SlaabyGlobal Drug Discovery, Novo Nordisk, Bagsværd, Denmark. risl@novonordisk.com.ORCID 0000-0002-2038-8466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes

Indexed as

Blood GlucoseGlucoseHypoglycemiaInsulinAnimalsFemaleGlucosidesHumansMacrocyclic CompoundsMaleRatsRats, Sprague-DawleyReceptor, InsulinSwineBlood GlucoseGlucoseGlucosidesInsulinMacrocyclic CompoundsReceptor, Insulin

Identifiers

PMID39415004
PMCPMC11499270

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.