ArticleNature2024
Dopamine dynamics are dispensable for movement but promote reward responses.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Acute fentanyl induces opposing directions of changes in tonic and phasic dopamine release patterns and impairs Pavlovian task performance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Region-specific weighting of sensory intensity and reward prediction error by dopamine signals.iScience · 2026Article
- Norepinephrine and dopamine sensor crosstalk depends on local innervation density.Nature neuroscience · 2026Article
- The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors.Communications biology · 2026Article
- Cerebellar neural populations orchestrate dopamine reward signaling with single-trial precision.Nature communications · 2026Article
- Prediction error correlates in the striosome-dopamine circuit emerge from information gain.Nature communications · 2026Article
- Midbrain endocannabinoids actuate dopamine-based action selection.Cell reports · 2026Article
- Cell-based regenerative interventions in Parkinson's disease: Overcoming pharmacological limitations.Acta pharmaceutica Sinica. B · 2026Review
- Sex-specific effects of exercise on motor coordination and extended basal ganglia physiology.bioRxiv : the preprint server for biology · 2026Article
- Visualizing Extracellular Dopamine Dynamics in the Retina Reveals a Biphasic Reduction During Initial Myopia Development.Investigative ophthalmology & visual science · 2026Article
- Article
- Rapid dopaminergic signatures in movement: Reach vigor reflects reward prediction error and learned expectation.Science advances · 2026Article
- An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement.bioRxiv : the preprint server for biology · 2026Article
- Apathy and Reduced Voluntary Activity in Older Adults with Parkinson's Disease: Mechanisms, Clinical Assessment, and Rehabilitation Implications.Clinical interventions in aging · 2026Review
- The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.bioRxiv : the preprint server for biology · 2025Article
- Subsecond dopamine fluctuations do not specify the vigor of ongoing actions.Nature neuroscience · 2025Article
- Timescales of dopamine release in the striatum as a window into hierarchical control.Current opinion in behavioral sciences · 2025Article
- Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning.Nature communications · 2025Article
- Glutamatergic synaptic resilience to overexpressed human alpha-synuclein.NPJ Parkinson's disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Xintong Cai *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Changliang Liu *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Iku Tsutsui-KimuraDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7554-4764
Joon-Hyuk LeeDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1984-7020
Chong GuoDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Aditi BanerjeeDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2016-0717
Jinoh LeeDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2158-8507
Ryunosuke AmoDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-8644-2296
Yudi XieDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-3624-0252
Tommaso PatriarchiInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-9351-3734
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID 0000-0002-9166-9919
Mitsuko Watabe-UchidaDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7864-754X
Naoshige UchidaDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-5755-9409
Pascal S KaeserDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. kaeser@hms.harvard.edu.ORCID 0000-0002-1558-1958
Funding
Towards a Unified Framework for Dopamine Signaling in the StriatumU19NS113201 · NINDS · HARVARD MEDICAL SCHOOL · PI DATTA, SANDEEP R · 2019 to 2023
$18.7MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MArchitecture and Function of Striatal Dopamine Signaling MachineryR01NS103484 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$4.7MMolecular Codes for the Establishment of Functionally Segregated Dopaminergic CircuitsR01MH125162 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI UMEMORI, HISASHI, WATABE-UCHIDA, MITSUKO · 2021 to 2025
$4.1MThe diversity of dopamine neurons: from connectivity and activity to functions.R01NS108740 · NINDS · HARVARD UNIVERSITY · PI UCHIDA, NAOSHIGE · 2018 to 2022
$2.7MMechanisms for somatodendritic dopamine release in the midbrainR01DA056109 · NIDA · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser, John T Williams · 2023 to 2026
$2.3MRoles for dopamine signaling modes in striatal circuit modulation and behaviorR01DA058777 · NIDA · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser, Naoshige Uchida · 2024 to 2026
$2.0MNICHD NIH HHS P50 HD105351NIDA NIH HHS R01 DA056109NIDA NIH HHS R01 DA058777NIMH NIH HHS R01 MH125162NINDS NIH HHS R01 NS103484NINDS NIH HHS R01 NS108740NINDS NIH HHS U19 NS113201
Abstract
Dopamine signalling modes differ in kinetics and spatial patterns of receptor activation
Indexed as
DopamineDopaminergic NeuronsMotivationMovementRewardAction PotentialsAnimalsCuesFemaleGTP-Binding ProteinsLevodopaMaleMiceMice, KnockoutProbabilityrab3 GTP-Binding ProteinsDopamineGTP-Binding ProteinsLevodoparab3 GTP-Binding ProteinsReceptors, DopamineReserpineRim2 protein, mouseRims1 protein, mouse
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.