ArticleNature2024
Neuropeptide signalling orchestrates T cell differentiation.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Targeting the neuro-immune-skin axis: Advanced functional biomaterials for intelligent wound management and regeneration.Materials today. Bio · 2026Review
- Neuroimmune interactions: from molecular mechanisms to therapeutic targets.Molecular biomedicine · 2026Review
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- Decoding age-stratified clinical and molecular heterogeneity in male breast cancer through multiomic profiling.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota.Science advances · 2026Article
- Wired for immunity: neuroimmune control of the lung by sensory neurons.Nature reviews. Neuroscience · 2026Review
- Bottom-Up Coacervate-Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life-Like Systems.Angewandte Chemie (International ed. in English) · 2026Review
- Sensory neuron-derived CCL5 orchestrates an immunosuppressive niche via regulatory T cells to fuel head and neck tumor progression.Journal for immunotherapy of cancer · 2026Article
- T-cell distribution in the dorsal root ganglion across species, sex, and age.bioRxiv : the preprint server for biology · 2026Article
- The dual role of TOX in regulating TNature immunology · 2026Article
- Comprehensive analysis of ATF3 as a diagnostic and prognostic biomarker from pan-cancer to clear cell renal cell carcinoma.Discover oncology · 2026Article
- The Neuroimmune Connectome: Understanding how the Peripheral Nervous System shapes Immunity.ImmunoHorizons · 2026Review
- Nociceptor neurons shape antiviral immunity.Journal of neuroinflammation · 2026Review
- Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity.Cell reports · 2026Article
- Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Meningeal neuropeptide and neuroimmune interactions in the context of migraine.The journal of headache and pain · 2026Review
- CRISPR-Cas9 Screening and Simulated Infection Transcriptomic Identify Key Drivers of Innate Immunity in Bactrian Camels.Animals : an open access journal from MDPI · 2026Article
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
25 authors.
Yu Hou *Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Linyu Sun *Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Martin W LaFleurGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5017-774X
Linglin HuangGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Conner LambdenGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Pratiksha I ThakoreBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kathryn Geiger-SchullerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kimitoshi KimuraGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Longjun YanLiangzhu Laboratory of Zhejiang University, Zhejiang University School of Medicine, Hangzhou, China.
Yue ZangLiangzhu Laboratory of Zhejiang University, Zhejiang University School of Medicine, Hangzhou, China.
Ruihan TangGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Jingwen ShiGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Rocky BarillaGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8062-7246
Liwen DengDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Ayshwarya SubramanianGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4134-7612
Antonia WallrappGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Hee Sun ChoiGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.
Yoon-Chul KyeGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0261-5247
Orr AshenbergBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Geoffrey SchiebingerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
John G DoenchGenetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3707-9889
Isaac M ChiuDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0723-4841
Aviv RegevBroad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.ORCID 0000-0003-3293-3158
Arlene H SharpeGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA. Arlene_Sharpe@hms.harvard.edu.ORCID 0000-0002-9736-2109
Vijay K KuchrooGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA. vkuchroo@bwh.harvard.edu.ORCID 0000-0001-7177-2110
Funding
Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5MTransgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 2008 to 2019
$17.1MProject 2: Genes required for dendritic cell responses to pathogens and T cellsU19AI133524 · NIAID · HARVARD MEDICAL SCHOOL · PI SHARPE, ARLENE H. · 2017 to 2021
$12.3MStaphylococcus aureus induced itch and neuro-immune signaling in skin infectionsR01AI168005 · NIAID · HARVARD MEDICAL SCHOOL · PI Isaac Ming-Cheng Chiu, ALEXANDER R HORSWILL · 2022 to 2026
$3.7MRole of Tim-3:Bat-3 pathway in inducing tolerogenic DCs and peripheral toleranceR01AI144166 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI VIJAY K. KUCHROO · 2020 to 2026
$3.2MNociceptor neuron regulation of gastrointestinal barrier protection and host defenseR01DK127257 · NIDDK · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2021 to 2024
$2.2MNeuroimmune interactions regulate development of allergic inflammationR37AI139536 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI VIJAY K. KUCHROO · 2024 to 2026
$1.8MNIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI073748NIAID NIH HHS R01 AI144166NIAID NIH HHS R01 AI168005NIAID NIH HHS R37 AI139536NIAID NIH HHS U19 AI133524NIDDK NIH HHS R01 DK127257
Abstract
The balance between T helper type 1 (T
Indexed as
Calcitonin Gene-Related PeptideCell DifferentiationSignal TransductionTh1 CellsTh2 CellsActivating Transcription Factor 3AnimalsCalcitonin Receptor-Like ProteinCyclic AMP Response Element-Binding ProteinFemaleMaleMiceMice, Inbred C57BLReceptor Activity-Modifying Protein 3STAT1 Transcription FactorActivating Transcription Factor 3Atf3 protein, mouseCalcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinCalcrl protein, mouseCyclic AMP Response Element-Binding ProteinRamp3 protein, mouseReceptor Activity-Modifying Protein 3STAT1 Transcription Factor
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.