Evidence mapPaperPMID 39415775Full record

ReviewNanoscale advances2024

Beyond aromatherapy: can essential oil loaded nanocarriers revolutionize cancer treatment?

Obaydah Abd Alkader Alabrahim, Jude Majed Lababidi, Wolfgang Fritzsche, Hassan Mohamed El-Said Azzazy

Abstract readReview
In one paragraph

Review in Nanoscale advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Nano-encapsulatedRSC advances · 2026
    Article
  2. Enhanced cytotoxic activity ofNanoscale advances · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Obaydah Abd Alkader AlabrahimDepartment of Chemistry, School of Sciences & Engineering, The American University in Cairo AUC Avenue, SSE # 1184, P.O. Box 74 New Cairo 11835 Egypt Obaydah.alabrahim@aucegypt.edu jlababidi@aucegypt.edu hazzazy@aucegypt.edu.ORCID https://orcid.org/0000-0003-0906-7597
Jude Majed LababidiDepartment of Chemistry, School of Sciences & Engineering, The American University in Cairo AUC Avenue, SSE # 1184, P.O. Box 74 New Cairo 11835 Egypt Obaydah.alabrahim@aucegypt.edu jlababidi@aucegypt.edu hazzazy@aucegypt.edu.
Wolfgang FritzscheDepartment of Nanobiophotonics, Leibniz Institute of Photonic Technology Albert Einstein Str. 9 Jena 07745 Germany.
Hassan Mohamed El-Said AzzazyDepartment of Chemistry, School of Sciences & Engineering, The American University in Cairo AUC Avenue, SSE # 1184, P.O. Box 74 New Cairo 11835 Egypt Obaydah.alabrahim@aucegypt.edu jlababidi@aucegypt.edu hazzazy@aucegypt.edu.ORCID https://orcid.org/0000-0003-2047-4222

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer, a complex global health burden, necessitates the development of innovative therapeutic strategies. While chemotherapy remains the primary treatment approach, its severe side effects and chemoresistance drive the search for novel alternatives. Essential oils (EOs), consisting of diverse bioactive phytochemicals, offer promise as anticancer agents. However, their limitations, such as instability, limited bioavailability, and non-specific targeting, hinder their therapeutic potential. These challenges were circumvented by utilizing nanoparticles and nanosystems as efficient delivery platforms for EOs. This review highlights the accumulating evidence based on loading EOs into several nanocarriers, including polymeric nanoparticles, nanoemulsions, nanofibers, lipid-based nanocapsules and nanostructures, niosomes, and liposomes, as effective anticancer regimens. It covers extraction and chemical composition of EOs, their mechanisms of action, and targeting strategies to various tumors. Additionally, it delves into the diverse landscape of nanocarriers, including their advantages and considerations for cancer targeting and EO encapsulation. The effectiveness of EO-loaded nanocarriers in cancer targeting and treatment is examined, highlighting enhanced cellular uptake, controlled drug release, and improved therapeutic efficacy. Finally, the review addresses existing challenges and future perspectives, emphasizing the potential for clinical translation and personalized medicine approaches.

Identifiers

PMID39415775
PMCPMC11474398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.