In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
15 authors.
Satarupa BhaduriSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0009-0004-9101-0040 Mac Kevin E BrazaSchool of Physical Sciences, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6929-7397 Stancho StanchevInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, 160 00, Czech Republic.ORCID 0000-0002-4880-0539 Marina TauberCenter for Biochemistry, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany.
Raghad Al-BawabSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Lawrence J LiuSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Diego F TrujilloSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Kristina Solorio-KirpichyanSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1260-2864 Ambuj SrivastavaSchool of Biological Sciences, Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1023-6124 Javier Sanlley-HernandezSchool of Biological Sciences, Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7032-0996 Anthony J O'DonoghueSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5695-0409 Marius K LembergCenter for Biochemistry, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID 0000-0002-0996-1268 Rommie AmarioSchool of Biological Sciences, Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-9275-9553 Kvido StrisovskyInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, 160 00, Czech Republic.ORCID 0000-0003-3677-0907 Sonya E NealSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-9618-8428 Funding
The Discovery of Molecules and Mechanisms of the Rhomboid SuperfamilyR35GM133565 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sonya Elina Neal · 2019 to 2026
$2.9MTumor-specific drug activation by pericellular proteasesR21CA256460 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI O'DONOGHUE, ANTHONY JOHN, OWEN, SHAWN C · 2022 to 2023
$409kNCI NIH HHS R21 CA256460NIGMS NIH HHS R35 GM133565
6 · The paper itselfAbstract
Rhomboid proteases are ubiquitous intramembrane serine proteases that can cleave transmembrane substrates within lipid bilayers. They exhibit many and diverse functions, such as but not limited to, growth factor signaling, immune and inflammatory response, protein quality control, and parasitic invasion. Human rhomboid protease RHBDL4 has been demonstrated to play a critical role in removing misfolded proteins from the Endoplasmic Reticulum and is implicated in severe diseases such as various cancers and Alzheimer's disease. Therefore, RHBDL4 is expected to constitute an important therapeutic target for such devastating diseases. Despite its critical role in many biological processes, the enzymatic properties of RHBDL4 remain largely unknown. To enable a comprehensive characterization of RHBDL4's kinetics, catalytic parameters, substrate specificity, and binding modality we expressed and purified recombinant RHBDL4, and employed it in a Förster Resonance Energy Transfer-based cleavage assay. Until now, kinetic studies have been limited mostly to bacterial rhomboid proteases. Our
Indexed as
endoplasmic-reticulum-associated protein degradationendoplasmic reticulum stressenzyme inhibitorenzyme kineticsenzyme purificationenzyme structureprotein misfoldingrhomboid proteaseserine protease
Identifiers
PMID39415989
PMCPMC11483055
What Socratic holds
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