Evidence map›Paper›PMID 39416010›Full record

ArticlebioRxiv : the preprint server for biology2024

Amylin receptor subunit interactions are modulated by agonists and determine signaling.

Sandra E Gostynska, Jordan A Karim, Bailee E Ford, Peyton H Gordon, Katie M Babin, Asuka Inoue, Nevin A Lambert, Augen A Pioszak

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sandra E GostynskaDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 73104. USA.
Jordan A KarimDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 73104. USA.
Bailee E FordDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 73104. USA.
Peyton H GordonDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 73104. USA.
Katie M BabinDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 73104. USA.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578. Japan.
Nevin A LambertDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA. 30912. USA.ORCID 0000-0001-7550-0921
Augen A PioszakDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 73104. USA.

Funding

RAMP-altered Class B GPCR Hormone RecognitionR01GM104251 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI PIOSZAK, AUGEN A · 2012 to 2024
$4.2M
Conventional and unconventional GPCR-G protein couplingR35GM145284 · NIGMS · AUGUSTA UNIVERSITY · PI Nevin Alan Lambert · 2022 to 2026
$1.8M
NIGMS NIH HHS R01 GM104251NIGMS NIH HHS R35 GM145284
6 · The paper itself

Abstract

Three amylin receptors (AMYRs) mediate the metabolic actions of the peptide hormone amylin and are drug targets for diabetes and obesity. AMY

Indexed as

BRETGPCRmembrane protein native PAGEpeptide hormoneRAMP

Identifiers

PMID39416010
PMCPMC11482831

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.