Evidence map›Paper›PMID 39416138›Full record

ArticlebioRxiv : the preprint server for biology2024

The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria.

Katherine Schubert, Micah Braly, Jessica Zhang, Michele E Muscolo, Hanh N Lam, Karen Hug, Henry Moore, Joshua W McCausland, Derfel Terciano, Todd Lowe and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Katherine SchubertDepartment of Molecular, Cell, and Developmental Biology, UC Santa Cruz, Santa Cruz, CA 95064, United States.
Micah BralyDepartment of Microbiology and Environmental Toxicology, UC Santa Cruz, Santa Cruz, CA 95064, United States.
Jessica ZhangDepartment of Biology, Stanford University, Stanford, CA 94305, United States.
Michele E MuscoloCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, United States.
Hanh N LamDepartment of Microbiology and Environmental Toxicology, UC Santa Cruz, Santa Cruz, CA 95064, United States.
Karen HugDepartment of Microbiology and Environmental Toxicology, UC Santa Cruz, Santa Cruz, CA 95064, United States.
Henry MooreDepartment of Biomolecular Engineering, UC Santa Cruz, Santa Cruz, CA 95064, United States.
Joshua W McCauslandDepartment of Biology, Stanford University, Stanford, CA 94305, United States.
Derfel TercianoDepartment of Microbiology and Environmental Toxicology, UC Santa Cruz, Santa Cruz, CA 95064, United States.
Todd LoweDepartment of Biomolecular Engineering, UC Santa Cruz, Santa Cruz, CA 95064, United States.
Cammie F LesserCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, United States.
Christine Jacobs-WagnerDepartment of Biology, Stanford University, Stanford, CA 94305, United States.
Helen WangDepartment of Medical Biochemistry and Microbiology, Uppsala University, Sweden.
Victoria AuerbuchDepartment of Microbiology and Environmental Toxicology, UC Santa Cruz, Santa Cruz, CA 95064, United States.ORCID 0000-0002-9475-4756

Funding

Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
Development of validated probes for the bacterial type III secretion systemR01AI141511 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STONE, VICTORIA AUERBUCH · 2019 to 2022
$3.0M
Dissecting the means by which type 3 substrates are defined & secretedR01AI128360 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LESSER, CAMMIE · 2019 to 2023
$2.8M
Combinatorial approach to develop novel pre-therapeutic agents targeting virulence factors essential to clinically relevant pathogensK99AI139281 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LAM, HANH NGOC · 2019 to 2021
$298k
NIAID NIH HHS K99 AI139281NIAID NIH HHS R01 AI128360NIAID NIH HHS R01 AI141511NIGMS NIH HHS T32 GM008646
6 · The paper itself

Abstract

Many species of pathogenic bacteria harbor critical plasmid-encoded virulence factors, and yet the regulation of plasmid replication is often poorly understood despite playing a critical role in plasmid-encoded gene expression. Human pathogenic

Identifiers

PMID39416138
PMCPMC11482874

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.