Evidence map›Paper›PMID 39416161›Full record

ArticlebioRxiv : the preprint server for biology2024

GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18.

Andrew S Wagner, Frances M Smith, David A Bennin, James A Votava, Rupsa Datta, Morgan A Giese, Wenxuan Zhao, Melissa C Skala, Jing Fan, Nancy P Keller and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Andrew S WagnerDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Frances M SmithDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
David A BenninDepartment of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
James A VotavaMorgridge Institute for Research, Madison, WI, USA.
Rupsa DattaMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0002-6432-2389
Morgan A GieseDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Wenxuan ZhaoMorgridge Institute for Research, Madison, WI, USA.
Melissa C SkalaMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0002-6320-7637
Jing FanDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0001-7940-6254

Funding

Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
Training human iPSC-derived neutrophils for antimicrobial functionR21AI184357 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI HUTTENLOCHER, ANNA · 2024 to 2025
$428k
Development and characterization of human iPSC-derived neutrophil therapies against pathogenic AspergilliF32AI183696 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WAGNER, ANDREW · 2024 to 2024
$50k
NIAID NIH HHS F32 AI183696NIAID NIH HHS R21 AI184357NIEHS NIH HHS T32 ES007015
6 · The paper itself

Abstract

Neutrophils are critical for host defense against fungi. However, the short life span and lack of genetic tractability of primary human neutrophils has limited

Identifiers

PMID39416161
PMCPMC11482877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.