ArticlebioRxiv : the preprint server for biology2024
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.
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38 authors.
Ahmad A CluntunDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-7612-8375
Joseph R ViskerNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8490-6111
Jesse N Velasco-SilvaDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-2656-5459
Marisa J LangDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-6236-9255
Luis Cedeño-RosarioDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-3085-327X
Thirupura S ShankarNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-5009-2770
Rana HamoucheNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9404-3866
Jing LingNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.
Ji Eon KimDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9776-0465
Ashish G ToshniwalDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Hayden K LowDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0009-0008-2100-5149
Corey N CunninghamDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-1755-4881
James CarringtonDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-4364-4020
Jonathan Leon CatrowDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Quentinn PearceDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0009-0008-5134-7190
Mi-Young JeongDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Alex J BottDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-2273-8922
Álvaro J Narbona-PérezDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Claire E StanleyDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Qing LiHigh-throughput Genomics Core, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
David R EberhardtNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-6538-8611
Jeffrey T MorganDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-3017-8665
Tarun YadavDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Chloe E WellsUniversity of Utah, Department of Pathology, Salt Lake City, UT 84112, USA.
Dinesh K A RamaduraiNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-0477-3778
Wojciech I SwiatekDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Dipayan ChaudhuriDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-0605-7334
Jeffery D RothsteinDepartment of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-2001-8470
Deborah M MuoioDepartments of Medicine and Pharmacology and Cancer Biology, and Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.ORCID 0000-0003-3760-9277
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7626-0034
Steven A BakerUniversity of Utah, Department of Pathology, Salt Lake City, UT 84112, USA.
Sutip NavankasattusasNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-6293-5627
James E CoxDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Katsuhiko FunaiDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3802-4756
Stavros G DrakosNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8626-7931
Jared RutterDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-2710-9765
Gregory S DuckerDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8651-6846
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jennifer Anne Doherty · 1986 to 2026
$72.6MTRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6MInterdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8MMetabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial CardiomyopathiesR01HL141353 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2018 to 2026
$4.3MPE methylation in skeletal muscle energy efficiencyR01DK107397 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2017 to 2025
$3.8MMitochondrial Biochemistry: From Mechanisms to DiseaseR35GM131854 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 2019 to 2026
$3.3MLOOH-induced muscle atrophy with ageR01AG074535 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Micah J Drummond, Katsuhiko Funai · 2022 to 2026
$3.0MRegulation of the mitochondrial calcium uniporterR01HL165797 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2022 to 2026
$2.5MMechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Mitral RegurgitationR01HL166513 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos · 2023 to 2026
$2.4MLands cycle and skeletal muscle insulin actionR01DK127979 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2022 to 2025
$1.9MClinical and Metabolic Signature of Recovered Myocardium in Human Heart FailureR01HL135121 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE · 2017 to 2021
$1.9MPE In Modulation of Energy Flux Through OxphosR01GM144613 · NIGMS · UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2021 to 2024
$1.6MBLRD VA I01 BX006306CSRD VA I01 CX002291NCI NIH HHS P30 CA042014NHLBI NIH HHS K99 HL168312NHLBI NIH HHS K99 HL175185NHLBI NIH HHS R00 HL168312NHLBI NIH HHS R01 HL135121NHLBI NIH HHS R01 HL141353NHLBI NIH HHS R01 HL165797NHLBI NIH HHS R01 HL166513NHLBI NIH HHS T32 HL007576NIA NIH HHS R01 AG074535NIDDK NIH HHS R01 DK107397NIDDK NIH HHS R01 DK127979NIDDK NIH HHS T32 DK091317NIGMS NIH HHS R01 GM144613NIGMS NIH HHS R35 GM131854
Abstract
Lactate is the highest turnover circulating metabolite in mammals. While traditionally viewed as a waste product, lactate is an important energy source for many organs, but first must be oxidized to pyruvate for entry into the tricarboxylic acid cycle (TCA cycle). This reaction is thought to occur in the cytosol, with pyruvate subsequently transported into mitochondria via the mitochondrial pyruvate carrier (MPC). Using
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.