Evidence map›Paper›PMID 39416671›Full record

ArticleJournal of extracellular biology2024

Comparison of nanoimaging and nanoflow based detection of extracellular vesicles at a single particle resolution.

Shihan Xu, Zhengrong Zhang, Bridgette C Melvin, Nibedita Basu Ray, Seiko Ikezu, Tsuneya Ikezu

Abstract read
In one paragraph

Article in Journal of extracellular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shihan XuDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.
Zhengrong ZhangDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.
Bridgette C MelvinDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.
Nibedita Basu RayDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.
Seiko IkezuDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.
Tsuneya IkezuDepartment of Neuroscience Mayo Clinic Florida Jacksonville Florida USA.ORCID https://orcid.org/0000-0002-3979-8596

Funding

Exosome-mediated propagation of pathogenic tau proteinRF1AG054199 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2016 to 2021
$5.0M
Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s diseaseR01AG054672 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, IKEZU, TSUNEYA · 2017 to 2021
$4.1M
Molecular characterization of extracellular vesicles for the spread of misfolded tau proteinR01AG067763 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2021 to 2025
$3.1M
Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse modelR01AG072719 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2021 to 2025
$2.7M
Therapeutic evaluation of targeting Tau Tubulin kinase-1 in Alzheimer’s diseaseR01AG079859 · NIA · MAYO CLINIC JACKSONVILLE · PI Seiko Ikezu · 2023 to 2026
$2.2M
Tumor susceptibility gene 101, a new microglial therapy candidate for Alzheimer’s disease to prevent cognitive declineRF1AG082704 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, SEIKO, IKEZU, TSUNEYA · 2023 to 2023
$2.0M
Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's diseaseR01AG066429 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2020 to 2024
$2.0M
NIA NIH HHS R01 AG054672NIA NIH HHS R01 AG066429NIA NIH HHS R01 AG067763NIA NIH HHS R01 AG072719NIA NIH HHS R01 AG079859NIA NIH HHS RF1 AG054199NIA NIH HHS RF1 AG082704
6 · The paper itself

Abstract

The characterization of single extracellular vesicle (EV) has been an emerging tool for the early detection of various diseases despite there being challenges regarding how to interpret data with different protocols or instruments. In this work, standard EV particles were characterized for single CD9

Indexed as

direct stochastic optical reconstruction microscopyextracellular vesiclemachine learningnanoflow cytometrynanoimaging

Identifiers

PMID39416671
PMCPMC11481688

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.