Evidence map›Paper›PMID 39417112›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Growth Rate Assessed by Vascular Deformation Mapping predicts Type B Aortic Dissection in Marfan Syndrome.

Carlos Alberto Campello Jorge, Prabhvir Singh Marway, Nicasius S Tjahjadi, Heather A Knauer, Himanshu J Patel, Marion Hofmann Bowman, Kim Eagle, Nicholas S Burris

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Carlos Alberto Campello JorgeDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0001-5290-7294
Prabhvir Singh MarwayDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-5768-4859
Nicasius S TjahjadiDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.ORCID 0009-0009-7377-2080
Heather A KnauerDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0001-8617-8958
Himanshu J PatelDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0001-7639-2416
Marion Hofmann BowmanDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-5529-6000
Kim EagleDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-0031-0191
Nicholas S BurrisDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-5198-4383

Funding

Non-invasive hemodynamic and biomechanic imaging methods for early risk prediction in aortic dissectionR01HL170059 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Nicholas Scott Burris, David Alexander Nordsletten · 2023 to 2026
$2.4M
Vascular Deformation Mapping (VDM) for Automated, 3D Assessment of Thoracic Aortic AneurysmR44HL145953 · NHLBI · IMBIO, LLC · PI BURRIS, NICHOLAS SCOTT, HATT, CHARLES R · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL170059NHLBI NIH HHS R44 HL145953
6 · The paper itself

Abstract

Background: Patients with Marfan syndrome (MFS) are at a high risk of type B dissection (TBAD). Aortic growth and elongation have been suggested as risk factors for TBAD. Vascular deformation mapping (VDM) is an image analysis technique for mapping 3D aortic growth on rouine computed tomography angiography (CTA) scans. We aimed to use VDM to examine the value of aortic growth rate in the descending thoracic aorta (DescAo), among other imaging biomarkers, to identify the factors associated with risk of TBAD in MFS. Methods and Results: CTA scans spanning 2004-2023 from adult MFS patients with native DescAo were analyzed by VDM. Other measurements included multi-level thoracoabdominal aortic diameters and the length of the DescAo by centerline analysis.Among the 105 MFS patients analyzed, 63.8% were male, with median age of 40 years (range 18-73) and a median surveillance interval of 5.3 years (range 2.0-18.3). During surveillance, 12 (11.4%) patients developed TBAD. Patients with TBAD had higher radial growth rate (0.63 vs. 0.23 mm/year; Conclusions: Radial growth and elongation rates of the DescAo were independent predictors of TBAD occurrence in MFS. TBAD often occurred in at non-aneurysmal diameters (<4.0 cm). These findings emphasize the role of growth over absolute diameter in risk stratification for TBAD in MFS.

Indexed as

computed tomography angiographygrowth rateMarfan syndrometype B aortic dissectionvascular deformation mapping

Identifiers

PMID39417112
PMCPMC11483026

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.