ArticlemedRxiv : the preprint server for health sciences2024
Genome-wide studies define new genetic mechanisms of IgA vasculitis.
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Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Comparison of long-term health-related quality of life and symptoms between COVID-19 patients and test-negative controls during the Omicron-predominant period in Japan.Archives of public health = Archives belges de sante publique · 2025Article
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Authors and funding
93 authors.
Lili LiuDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.ORCID 0000-0002-2622-9669
Li ZhuRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Sara Monteiro-MartinsInstitute of Genetic Epidemiology, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Aaron GriffinDepartment of Systems Biology, Columbia University, New York, NY, USA.
Lukas J VlahosDepartment of Systems Biology, Columbia University, New York, NY, USA.
Masashi FujitaDivision of Neuroimmunology, Department of Neurology, Columbia University, New York, NY, USA.
Cecilia BerrouetDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Francesca ZanoniDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Maddalena MarasaDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Jun Y ZhangDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Xu-Jie ZhouRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Yasar CaliskanDivision of Nephrology, Saint Louis University, Saint Louis, MO, USA.
Oleh AkchurinWeill Cornell Medical Center, New York, NY, USA.
Samhar Al-AkashDriscoll Children's Hospital, Corpus Christi, TX, USA.
Augustina JankauskieneInstitute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
Monica BodriaMONICA BODRIA, MD, PHD, Primary Care Unit, Ausl Parma, south east district, Parma, Italy.
Aftab ChishtiDivision of Pediatric Nephrology, University of Kentucky, Kentucky Children's Hospital, Lexington, KY, USA.
Ciro EspositoIstituti Clinico Scientifici Maugeri IRCCS, University of Pavia, Pavia, Italy.
Vittoria EspositoIstituti Clinico Scientifici Maugeri IRCCS, University of Pavia, Pavia, Italy.
Donna ClaesCinncinnati Children's Hospital, Cincinnati, OH, USA.
Vladimir TesarDepartment of Nephrology, 1st School of Medicine, Charles University Prague, Czech Republic.
Thomas K DavisWashington University in Saint Louis, MO, USA.
Dmitry SamsonovMaria Fareri Children's Hospital (MCF), New York Medical College, New York, NY, USA.
Dorota KaminskaDepartment of Non-Procedural Clinical Sciences, Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland.
Tomasz Hryszko2nd Department of Nephrology, Hypertension and Internal Medicine, Medical University of Bialystok, Poland.
Gianluigi ZazaRenal, Dialysis and Transplant Unit, Department of Pharmacy, Health and Nutritional Sciences (DFSSN), University of Calabria.
Joseph T FlynnDepartment of Pediatrics, University of Washington; and Division of Nephrology, Seattle Children's Hospital.
Franca IoremberPhoenix Children's Hospital, Phoenix, AZ, USA.
Francesca LuganiIRCCS Istituto Giannina Gaslini, Genoa, Italy.ORCID 0000-0001-7232-7975
Dana RizkUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Bruce A JulianUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Guillermo HidalgoEast Carolina University, Greenville, NC, USA.
Mahmoud KallashSUNY Buffalo, Buffalo, NY, USA.
Luigi BianconeUniversity of Turin, Italy.
Antonio AmorosoUniversity of Turin, Italy.
Luisa BonoNephrology and Dialysis, A.R.N.A.S. Civico and Benfratellio, Palermo, Italy.
Laila-Yasmin ManiDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Bruno VogtDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Fangming LinDivision of Pediatric Nephrology, Department of Medicine, Columbia University, New York, NY, USA.
Raji SreedharanMedical College of Wisconsin, Madison, WI, USA.
Patricia WengUniversity of California in Los Angeles, CA, USA.
Daniel RanchUT Health San Antonio, San Antonio, TX, USA.
Nianzhou XiaoValley Children's Healthcare, Madera, CA, USA.
Alejandro QuirogaHelen DeVos Children's Hospital, Grand Rapids, MI, USA.
Raed Bou MatarCleveland Clinic, Cleveland, OH, USA.
Michelle N RheaultUniversity of Minnesota, Minneapolis, MN, USA.
Scott WenderferTexas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Dave SelewskiMott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
Sigrid LundbergDanderyd University Hospital, Karolinska Institute, Stockholm, Sweden.
Cynthia SilvaConnecticut Children's Medical Center, Hartford, CT, USA.
Sherene MasonConnecticut Children's Medical Center, Hartford, CT, USA.
John D MahanNationwide Children's Hospital, Columbus, OH, USA.
Tetyana L VasylyevaTexas Tech University Health Sciences Center, Amarillo, TX, USA.
Krzysztof MuchaDepartment of Transplantology, Immunology, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Bartosz ForoncewiczDepartment of Transplantology, Immunology, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Leszek PączekDepartment of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.
Michał FlorczakDepartment of Transplantology, Immunology, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Małgorzata OlszewskaDepartment of Dermatology, Medical University of Warsaw, Warsaw, Poland.
Agnieszka GradzińskaDepartment of Dermatology and Pediatric Dermatology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Maria SzczepańskaDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Edyta MachuraDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Andrzej BadeńskiDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Helena KrakowczykDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Przemysław SikoraDepartment of Pediatric Nephrology, Medical University of Lublin, Lublin, Poland.
Norbert KwellaDepartment of Nephrology, Transplantology and Internal Diseases, University of Warmia and Mazury, Olsztyn, Poland.
Monika MiklaszewskaDepartment of Pediatric Nephrology and Hypertension, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
Dorota DrożdżDepartment of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Krakow, Poland.
Marcin ZaniewDepartment of Pediatrics, University of Zielona Góra, Zielona Góra, Poland.
Krzysztof PawlaczykDepartment of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Katarzyna SiniewiczLuzeńczykDepartment of Paediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
Andrew S BombackColumbia University Medical Center, New York, NY, US.
Gerald B AppelColumbia University Medical Center, New York, NY, US.
Claudia IzziDepartment of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Francesco ScolariDepartment of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Anna Materna-KirylukDepartment of Genetics, Medical University of Poznan, Poznan, Poland.
Malgorzata Mizerska-WasiakDepartment of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.
Laureline BerthelotNantes University, Inserm, CR2TI Center of Research on Translational Transplantation and Immunology, Nantes, France.
Evangeline PilleboutCenter for Research on Inflammation, Paris Cité University, INSERM and CNRS, Paris, France.
Renato C MonteiroCenter for Research on Inflammation, Paris Cité University, INSERM and CNRS, Paris, France.
Jan NovakUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Todd Jason GreenUniversity of Alabama at Birmingham, Birmingham, AL, USA.
William E SmoyerNationwide Children's Hospital, Columbus, OH, USA.
M Colleen HastingsUniversity of Tennessee Health Science Center, Memphis, TN, USA.
Robert J WyattDepartment of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee.
Raoul NelsonUniversity of Utah, Salt Lake City, UT, USA.
Javier MartinInstitute of Parasitology and Biomedicine Lopez-Neyra, Spanish National Research Council (CSIC), Granada, Spain.
Miguel A González-GayDivision of Rheumatology, IIS-Fundación Jiménez Díaz, Madrid, Spain.
Philip L De JagerDivision of Neuroimmunology, Department of Neurology, Columbia University, New York, NY, USA.ORCID 0000-0002-8057-2505
Anna KöttgenInstitute of Genetic Epidemiology, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Andrea CalifanoDepartment of Systems Biology, Columbia University, New York, NY, USA.
Ali G GharaviDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Hong ZhangRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Krzysztof KirylukDepartment of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1MPredicting Cancer Cell Response to Endogenous and Exogenous Perturbations at the Single Cell LevelR35CA197745 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANDREA CALIFANO · 2015 to 2026
$11.5MElucidating IgA Nephropathy through Genetic Studies of IgA1 GlycosylationR01DK082753 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GHARAVI, ALI G, NOVAK, JAN · 2009 to 2024
$8.7MMolecular Basis of Pathogenicity of IgA1-containing Immune ComplexesR01DK078244 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAN NOVAK · 2007 to 2026
$6.0MGenomics of glomerular diseaseRC2DK116690 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIRYLUK, KRZYSZTOF, KRETZLER, MATTHIAS · 2018 to 2022
$5.0MGenetics of IgA nephropathy by integrative network-based association studiesR01DK105124 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Krzysztof Kiryluk · 2015 to 2026
$4.8MPathogenic Autoantibodies with Specificity for Aberrant Glycoproteins: Assessment of a Therapeutic Target in an Autoimmune DiseaseR01AI149431 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GREEN, TODD JASON, NOVAK, JAN · 2020 to 2024
$2.6MUncovering novel mechanisms and potential therapeutic targets for IgA vasculitis through GWAS and systems-level analysis of regulatory networks.K01DK137031 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lili Liu · 2023 to 2026
$613kIdentifying and Targeting Master Regulators of Drug Resistance in Lung Adenocarcinoma through Network Analysis of Tumor Transcriptomic DataF30CA257765 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GRIFFIN, AARON TIMOTHY · 2021 to 2023
$146kMolecular Basis of Pathogenicity of IgA1-containing Immune ComplexesR56DK078244 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NOVAK, JAN · 2012 to 2012
$92kNCI NIH HHS F30 CA257765NCI NIH HHS R35 CA197745NIAID NIH HHS R01 AI149431NIDDK NIH HHS K01 DK137031NIDDK NIH HHS R01 DK078244NIDDK NIH HHS R01 DK082753NIDDK NIH HHS R01 DK105124NIDDK NIH HHS R56 DK078244NIDDK NIH HHS RC2 DK116690NIGMS NIH HHS T32 GM007367
Abstract
IgA vasculitis (IgAV) is a pediatric disease with skin and systemic manifestations. Here, we conducted genome, transcriptome, and proteome-wide association studies in 2,170 IgAV cases and 5,928 controls, generated IgAV-specific maps of gene expression and splicing from blood of 255 pediatric cases, and reconstructed myeloid-specific regulatory networks to define disease master regulators modulated by the newly identified disease driver genes. We observed significant association at the
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