Evidence map›Paper›PMID 39417448›Full record

ReviewBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2024

Mesenchymal stem cells from different sources for sepsis treatment: prospects and limitations.

Heng Chen, Xiaosui Ling, Bo Zhao, Jing Chen, XianYi Sun, Jing Yang, Pibao Li

Abstract readReview
In one paragraph

Review in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heng ChenShandong University of Traditional Chinese Medicine, Jinan, Shandong, China.ORCID http://orcid.org/0009-0001-0833-027X
Xiaosui LingThe Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0003-4514-0886
Bo ZhaoDepartment of Intensive Care Unit, The First Rehabilitation Hospital of Shandong, Linyi, Shandong, China.ORCID http://orcid.org/0009-0006-6479-1704
Jing ChenDepartment of Forensic Medicine, Yuancheng District Public Security Bureau, Heyuan, Guangdong, China.ORCID http://orcid.org/0009-0004-5601-1021
XianYi SunDepartment of Intensive Care Unit, The First Rehabilitation Hospital of Shandong, Linyi, Shandong, China.ORCID http://orcid.org/0009-0003-6588-2956
Jing YangDepartment of Pharmacy, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0003-1634-226X
Pibao LiDepartment of Intensive Care Unit, The First Rehabilitation Hospital of Shandong, Linyi, Shandong, China.ORCID http://orcid.org/0000-0003-3944-5106

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a systemic inflammatory response syndrome in which the host response to infection is dysregulated, leading to circulatory dysfunction and multi-organ damage. It has a high mortality rate and its incidence is increasing year by year, posing a serious threat to human life and health. Mesenchymal stem cells (MSC) have the following properties: hematopoietic support, provision of nutrients, activation of endogenous stem/progenitor cells, repair of tissue damage, elimination of inflammation, immunomodulation, promotion of neovascularization, chemotaxis and migration, anti-apoptosis, anti-oxidation, anti-fibrosis, homing, and many other effects. A large number of studies have confirmed that MSC from different sources have their own characteristics. This article reviews the pathogenesis of sepsis, the biological properties of MSC, and the advantages and disadvantages of different sources of MSC for the treatment of sepsis and their characteristics.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationSepsisHumans

Identifiers

PMID39417448
PMCPMC11484354

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.