Trial reportIntensive care medicine2024
Fluid balance neutralization secured by hemodynamic monitoring versus protocolized standard of care in patients with acute circulatory failure requiring continuous renal replacement therapy: results of the GO NEUTRAL randomized controlled trial.
Trial report in Intensive care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07643597 (Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3-fluid removal at de-escalation phase.Intensive care medicine · 2025Guideline
- Factors associated with adverse haemodynamic events during the STARRT-AKI trial: a post-hoc secondary analysis.Critical care (London, England) · 2025Trial
- Diagnostic performance of a 250-ml net ultrafiltration challenge to identify risk of preload-dependence in critically ill patients undergoing continuous renal replacement therapy: a randomized, cross-over trial.Critical care (London, England) · 2025Trial
- Personalized positive end-expiratory pressure in spontaneously breathing patients with acute respiratory distress syndrome by simultaneous electrical impedance tomography and transpulmonary pressure monitoring: a randomized crossover trial.Intensive care medicine · 2024Trial
- Dynamic indices of fluid responsiveness: physiological basis and clinical limits.Intensive care medicine · 2026Article
- The role of thoracic ultrasound in fluid management in critical care: a narrative review.Journal of thoracic disease · 2026Review
- Ultrafiltration in the critically ill patient: a framework for personalized care.Critical care (London, England) · 2026Review
- Discrepancies between declared and real practices of continuous renal replacement therapy for septic acute kidney injury in French intensive care units.Annals of intensive care · 2026Article
- The time course of fluid responsiveness.Annals of intensive care · 2026Review
- How to perform fluid de-escalation in critical care.Annals of intensive care · 2026Review
- Renal congestion syndrome in critically ill patients: a neglected mechanism of acute kidney injury - A narrative review.Annals of intensive care · 2026Review
- Extracorporeal circuit temperature gradient and hemodynamic instability during continuous renal replacement therapy: an observational study.Annals of intensive care · 2026Article
- From "when to stop" to "why continue today?": operationalizing RRT weaning with UUEI.Critical care (London, England) · 2025Article
- Reply to 'Methodological considerations on early cumulative fluid balance and mortality in post-cardiac arrest shock'.Resuscitation plus · 2025Article
- Fluid balance and outcome in cardiac arrest patients admitted to intensive care unit.Critical care (London, England) · 2025Observational
- Proactive Prescription-Based Fluid Management Versus Usual Care in Critically Ill Patients on Kidney Replacement Therapy (Probe-Fluid): A Pilot Clinical Trial Protocol.Canadian journal of kidney health and disease · 2025Article
- Spontaneous tumor lysis syndrome following liver biopsy: a case report and literature review.Frontiers in oncology · 2025Article
- Protocolized fluid balance neutralization during continuous renal replacement therapy.Intensive care medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
purposeNet ultrafiltration (UF
methodsIn this randomized, controlled, open-label, parallel-group, multicenter, proof-of-concept trial, adults receiving vasopressors, CRRT since ≤ 24 h and cardiac output monitoring were randomized (ratio 1:1) to receive during 72 h a UF
resultsBetween June 2021 and April 2023, 55 patients (age 69 [interquartile range, IQR: 62; 74], 35% female, Sequential Organ Failure Assessment (SOFA) 13 [11; 15]) were randomized (25 interventions, 30 controls). In the mITT population, (21 interventions, 24 controls), the 72 h FB was -2650 [-4574; -309] ml in the intervention arm, and 1841 [821; 5327] ml in controls (difference: 4942 [95% confidence interval: 2736-6902] ml, P < 0.01). Hemodynamics, oxygenation and the number of HIRRT at 72 h, and day-90 mortality did not statistically differ between arms.
conclusionIn patients with vasopressors, a UF
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.