Evidence mapPaperPMID 39418113Full record

ArticleInhalation toxicology

Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice.

Olivia F McDonald, James G Wagner, Ryan P Lewandowski, Lauren K Heine, Vanessa Estrada, Elham Pourmand, Megha Singhal, Jack R Harkema, Kin Sing Stephen Lee, James J Pestka

Abstract read
In one paragraph

Article in Inhalation toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olivia F McDonaldDepartment of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
James G WagnerInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.
Ryan P LewandowskiDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.
Lauren K HeineDepartment of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
Vanessa EstradaDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Elham PourmandDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Megha SinghalDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Jack R HarkemaDepartment of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
Kin Sing Stephen LeeDepartment of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
James J PestkaInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.

Funding

Role of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.R01ES027353 · NIEHS · MICHIGAN STATE UNIVERSITY · 2024 to 2025
$1.2M
Integrative Pharmacological Sciences Training Program (IPSTP)T32GM142521 · MICHIGAN STATE UNIVERSITY · 2025 to 2025
$410k
Ferroptosis and Polyunsaturated Fatty Acid MetabolismR35GM146983 · MICHIGAN STATE UNIVERSITY · 2025 to 2025
$391k
NIEHS NIH HHS R01 ES027353NIGMS NIH HHS R35 GM146983NIGMS NIH HHS T32 GM142521
6 · The paper itself

Abstract

objectiveAcute intranasal (IN) instillation of lupus-prone NZBWF1 mice with crystalline silica (cSiO

methodsFemale 6-week-old NZBWF1 mice were fed control or TPPU-supplemented diets for 2 weeks then IN instilled with 2.5 mg cSiO

resultscSiO DISCUSSION: cSiO

Indexed as

AutoantibodiesEpoxide HydrolasesPulmonary FibrosisSilicon DioxideAnimalsCytokinesEnzyme InhibitorsFemaleLungLupus Erythematosus, SystemicLymphocytesMicePhenylurea CompoundsPiperidines1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)ureaAutoantibodiesCytokinesEnzyme InhibitorsEpoxide HydrolasesPhenylurea CompoundsPiperidinesSilicon Dioxidecrystalline silicaectopic lymphoid structurelungNZBWF1 miceprostaglandinPulmonary fibrosissoluble epoxide hydrolase

Identifiers

PMID39418113
PMCPMC11606782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.