Evidence map›Paper›PMID 39419434›Full record

ArticleExperimental neurology2025

Preventive effects of transcranial photobiomodulation on epileptogenesis in a kainic acid-induced rat epilepsy model.

Jing You, Jannon Fuchs, Miaomiao Wang, Qichan Hu, Xiaoxiao Tao, Elizabeth Krolczyk, Tanya Tirumala, Anatol Bragin, Hanli Liu, Jerome Engel and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jing YouDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Jannon FuchsDepartment of Biological Sciences, University of North Texas, Denton, TX, USA.
Miaomiao WangDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Qichan HuDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Xiaoxiao TaoDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Elizabeth KrolczykDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Tanya TirumalaDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Anatol BraginDepartment of Neurology, University of California Los Angeles, Los Angeles, California, USA; Brain Research Institute, University of California, Los Angeles, California, USA.
Hanli LiuDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, USA.
Jerome EngelDepartment of Neurology, University of California Los Angeles, Los Angeles, California, USA; Brain Research Institute, University of California, Los Angeles, California, USA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, California, USA.
Lin LiDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA; Department of Neurology, University of California Los Angeles, Los Angeles, California, USA. Electronic address: lin.li@unt.edu.

Funding

In Vivo Studies of the Epileptic HippocampusRF1NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, STABA, RICHARD · 2023 to 2023
$3.6M
New approach for identification pHFO networks to predict epileptogenesisR16NS131108 · NINDS · UNIVERSITY OF NORTH TEXAS · PI Lin Li · 2022 to 2026
$1.3M
NINDS NIH HHS R16 NS131108NINDS NIH HHS RF1 NS033310
6 · The paper itself

Abstract

objectiveTemporal lobe epilepsy affects nearly 50 million people worldwide and is a major burden to families and society. A significant portion of patients are living in developing countries with limited access to therapeutic resources. This highlights the urgent need to develop more readily available, noninvasive treatments for seizure control. This research explored the effectiveness of transcranial photobiomodulation (tPBM), a non-invasive method utilizing photon-tissue interactions, for preventing epileptogenesis and controlling seizures.

methodsIn a kainic acid (KA)-induced rat model of epilepsy, two different wavelengths of tPBM, 808 nm and 940 nm, were applied separately in two groups of animals (KA+808 and KA+940). The ability of tPBM for seizure control was evaluated by comparing the occurrence rate of interictal epileptiform discharges (IED) and behavioral seizures among three groups: KA, KA+808, KA+940. Prevention of epileptogenesis was assessed by comparing the occurrence rate of high frequency oscillations (HFOs), especially fast ripple (FR) rate, among the three groups. Nissl staining and immunostaining for the apoptosis marker caspase-3 were used as indications of neuroprotection.

resultsThe KA+808 group and the KA+940 group showed significantly lower FR and IED rates compared to the KA group. Weekly FR rates started to drop during the first week of tPBM treatment. The KA+808 and KA+940 groups also displayed milder seizure behaviors and less neuronal loss in hippocampal areas compared to KA rats without tPBM treatment. Similarly, lower caspase-3 levels in the KA+808 and KA+940 compared with the KA group suggested effectiveness of tPBM in reducing cell death. SIGNIFICANCE: tPBM of 808 nm/940 nm showed effectiveness in suppressing epileptogenesis and ictogenesis in the KA-induced rat epilepsy model. This effectiveness of tPBM can be linked to the neuroprotection benefits of photon-tissue interactions. Further studies are warranted to elucidate the fundamental mechanism of tPBM protection, determine optimal treatment parameters and validate its effectiveness in other epilepsy models.

Indexed as

Disease Models, AnimalEpilepsyKainic AcidLow-Level Light TherapyRats, Sprague-DawleyAnimalsElectroencephalographyExcitatory Amino Acid AgonistsHippocampusMaleRatsExcitatory Amino Acid AgonistsKainic AcidCaspase-3EpileptogenesisHigh-frequency oscillationsInterictal epileptiform dischargesKainic acidNeuroprotectionSeizure controlTemporal lobe epilepsyTranscranial photobiomodulation

Identifiers

PMID39419434
PMCPMC12282527

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.