Evidence map›Paper›PMID 39419462›Full record

ArticleBiological psychiatry2025

Adenosine A

Nicholas Petersen, Katharine E McCann, Mihaela A Stavarache, Lisa Y Kim, David Weinshenker, Danny G Winder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicholas PetersenMolecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee.
Katharine E McCannHuman Genetics, Emory University School of Medicine, Atlanta, Georgia; Neuroscience Undergraduate Program, School of Psychology, Georgia Institute of Technology, Atlanta, Georgia.
Mihaela A StavaracheNeurosurgery, Weill Cornell Medical College, New York, New York.
Lisa Y KimSchool for Science and Math at Vanderbilt, Nashville, Tennessee.
David WeinshenkerHuman Genetics, Emory University School of Medicine, Atlanta, Georgia.
Danny G WinderMolecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee; Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts. Electronic address: danny.winder@umassmed.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Norepinephrine-dopamine interactions underlying arousalR01NS102306 · NINDS · EMORY UNIVERSITY · PI MITRANO, DARLENE A, WEINSHENKER, DAVID · 2017 to 2021
$1.8M
Ethanol modulation of a NE-astrocyte-DA arousal pathwayR01AA031269 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Danny G. Winder · 2024 to 2026
$1.5M
Neuron-astrocyte interactions mediating ethanol and noradrenergic modulation of wake-promoting vPAG dopamine neuronsF30AA029599 · NIAAA · VANDERBILT UNIVERSITY · PI PETERSEN, NICHOLAS · 2022 to 2024
$115k
NIAAA NIH HHS F30 AA029599NIAAA NIH HHS R01 AA031269NIGMS NIH HHS T32 GM007347NINDS NIH HHS R01 NS102306
6 · The paper itself

Abstract

backgroundSleep and arousal disorders are common, but the underlying physiology of wakefulness is not fully understood. The locus coeruleus promotes arousal via α

methodsIn this study, we utilized genetic manipulations with ex vivo calcium imaging in vPAG

resultsActivation of α

conclusionsWe have identified a crucial role for vPAG astrocytic α

Indexed as

AstrocytesDopaminergic NeuronsReceptor, Adenosine A2AReceptors, Adrenergic, alpha-1WakefulnessAdenosineAnimalsMaleMiceMice, Inbred C57BLPeriaqueductal GraySignal TransductionAdenosineReceptor, Adenosine A2AReceptors, Adrenergic, alpha-1Adenosine A(2A) receptorArousalAstrocytesDopamine neuronsNorepinephrineSleep-wake regulationVentral periaqueductal grayα(1)-adrenergic receptor

Identifiers

PMID39419462
PMCPMC11991893

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.