Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Kenzui TaniueIsotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan. kenzui@ric.u-tokyo.ac.jp.ORCID 0000-0003-3660-3009
Anzu SugawaraIsotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Chao ZengFaculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.ORCID 0000-0002-6130-2438
Han HanIsotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Xinyue GaoIsotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Yuki ShimouraIsotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Atsuko Nakanishi OzekiIsotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Rena Onoguchi-MizutaniIsotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Masahide SekiDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8561, Japan.ORCID 0000-0001-6091-8698
Yutaka SuzukiDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8561, Japan.ORCID 0000-0003-4852-1879
Michiaki HamadaFaculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.ORCID 0000-0001-9466-1034
Nobuyoshi AkimitsuIsotope Science Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan. akimitsu@ric.u-tokyo.ac.jp.ORCID 0000-0002-3190-2942
Funding
Japan Agency for Medical Research and Development (AMED) JP21ae0121049MEXT | Japan Society for the Promotion of Science (JSPS) 17KK0163MEXT | Japan Society for the Promotion of Science (JSPS) 20H00624MEXT | Japan Society for the Promotion of Science (JSPS) 21H00243MEXT | Japan Society for the Promotion of Science (JSPS) 21H02758MEXT | Japan Society for the Promotion of Science (JSPS) 21H04792MEXT | Japan Society for the Promotion of Science (JSPS) 21K19402MEXT | Japan Society for the Promotion of Science (JSPS) 22H04925MEXT | Japan Society for the Promotion of Science (JSPS) 22K15093MEXT | Japan Society for the Promotion of Science (JSPS) 22KK0285MEXT | Japan Society for the Promotion of Science (JSPS) 23H04955
6 · The paper itself
Abstract
RNA surveillance systems degrade aberrant RNAs that result from defective transcriptional termination, splicing, and polyadenylation. Defective RNAs in the nucleus are recognized by RNA-binding proteins and MTR4, and are degraded by the RNA exosome complex. Here, we detect aberrant RNAs in MTR4-depleted cells using long-read direct RNA sequencing and 3' sequencing. MTR4 destabilizes intronic polyadenylated transcripts generated by transcriptional read-through over one or more exons, termed 3' eXtended Transcripts (3XTs). MTR4 also associates with hnRNPK, which recognizes 3XTs with multiple exons. Moreover, the aberrant protein translated from KCTD13 3XT is a target of the hnRNPK-MTR4-RNA exosome pathway and forms aberrant condensates, which we name KCTD13 3eXtended Transcript-derived protein (KeXT) bodies. Our results suggest that RNA surveillance in human cells inhibits the formation of condensates of a defective polyadenylated transcript-derived protein.
Indexed as
ExonsHeterogeneous-Nuclear Ribonucleoprotein KRNA-Binding ProteinsRNA, MessengerExosome Multienzyme Ribonuclease ComplexHEK293 CellsHeLa CellsHumansIntronsNucleocytoplasmic Transport ProteinsPolyadenylationRNA NucleotidyltransferasesExosome Multienzyme Ribonuclease ComplexHeterogeneous-Nuclear Ribonucleoprotein KHNRNPK protein, humanNucleocytoplasmic Transport ProteinsRNA-Binding ProteinsRNA, MessengerRNA NucleotidyltransferasesTENT4B protein, human
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
The MTR4/hnRNPK complex surveils aberrant polyadenylated RNAs with multiple exons. · full record | Socratic