Evidence map›Paper›PMID 39420001›Full record

ArticleNature communications2024

Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome.

Maiko Matsui, Lauren E Lynch, Isabella Distefano, Allison Galante, Aravind R Gade, Hong-Gang Wang, Nicolas Gómez-Banoy, Patrick Towers, Daniel S Sinden, Eric Q Wei and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Maiko MatsuiCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Lauren E LynchCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.ORCID 0000-0002-5371-335X
Isabella DistefanoCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Allison GalanteCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Aravind R GadeCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Hong-Gang WangCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Nicolas Gómez-BanoyCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.ORCID 0000-0002-3552-1768
Patrick TowersCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Daniel S SindenCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Eric Q WeiDepartment of Medicine, MSRB II, 2 Genome Ct, Duke University Medical Center, Durham, NC, 27710, USA.
Adam S BarnettDepartment of Medicine, MSRB II, 2 Genome Ct, Duke University Medical Center, Durham, NC, 27710, USA.
Kenneth JohnsonCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Renan LimaWeill Center for Metabolic Health, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Alfonso Rubio-NavarroCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Ang K LiCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Steven O MarxDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, 622 W 168th St, PH-3 Center, New York, NY, USA.ORCID 0000-0002-0577-6030
Timothy E McGrawDepartment of Biochemistry, Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA.ORCID 0000-0001-9748-263X
Paul S ThorntonDivision of Endocrinology and Diabetes, Cook Children's Medical Center, 801 7th Ave, Fort Worth, TX, 76104, USA.
Katherine W TimothyChildren's Hospital Boston, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
James C LoCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA.
Geoffrey S PittCardiovascular Research Institute, Weill Cornell Medicine, 413 E. 69th St., New York, NY, 10021, USA. geoffrey.pitt@med.cornell.edu.ORCID 0000-0003-2246-0289

Funding

Investigating the role of CaV1.2 in aortic valve stenosisR01HL151190 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2020 to 2023
$3.2M
Dusp26 regulation of beta cell homeostasisR01DK121140 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI James C Lo · 2020 to 2026
$2.7M
Investigation of the roles for CaV1.2 in non-excitable tissue during developmentR01HD090132 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2016 to 2020
$2.3M
An Obesity-Induced Kinase that Regulates Adipose Homeostasis and Metabolic DiseasesR01DK121844 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI LO, JAMES C · 2019 to 2023
$2.1M
Genetic and Environmental Influences on AddictionT32DA039080 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Teresa A Milner · 2017 to 2026
$1.4M
NHLBI NIH HHS R01 HL151190NICHD NIH HHS R01 HD090132NIDA NIH HHS T32 DA039080NIDDK NIH HHS R01 DK121140NIDDK NIH HHS R01 DK121844
6 · The paper itself

Abstract

The canonical G406R mutation that increases Ca

Indexed as

Autistic DisorderCalcium Channels, L-TypeDisease Models, AnimalHypoglycemiaInsulin-Secreting CellsLong QT SyndromeSyndactylyAnimalsBlood GlucoseCalciumFemaleGene Knock-In TechniquesGlucagonGlucoseHomeostasisHumansBlood GlucoseCACNA1C protein, mouseCalciumCalcium Channels, L-TypeGlucagonGlucoseInsulin

Identifiers

PMID39420001
PMCPMC11487186

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.