ArticleNature immunology2024
A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5.
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
–field-weighted citation impact
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Who cites it
14 citing papers in PubMed.
- Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease.Nature reviews. Immunology · 2026Review
- Photopolymerizable placenta-derived ECM hydrogel enhances hUC-MSC-mediated wound healing via coordinated immunomodulation and angiogenesis.Materials today. Bio · 2026Article
- Differential NAD + availability may drive asymmetric SIRT7 activity in tumor and immune cells.Molecular biology reports · 2026Review
- Current Understanding of SIRT7 Function and Its Emerging Roles in the Central Nervous System.Cells · 2026Review
- RACK1 in host immune response to infections: molecular mechanisms and therapeutic potentials.Frontiers in immunology · 2026Review
- A Double-Edged Role for SIRT7 in Cancer: Can Anti-Cancer Immunity Tip the Balance?Pharmaceuticals (Basel, Switzerland) · 2025Review
- SIRT7 drives energy metabolic shifts in endometriosis via interaction with TUFM and Rhoa/Rock/Akt pathway activation.Cellular and molecular life sciences : CMLS · 2025Article
- Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC.Molecular cancer · 2025Article
- Review
- Structural basis of SIRT7 nucleosome engagement and substrate specificity.Nature communications · 2025Article
- Sirtuins and tumor immunity: mechanistic insights, immunotherapy prospects, and therapeutic horizons.Frontiers in immunology · 2025Review
- Integrative MultiOmics and Machine Learning Reveal Peroxiredoxin 4 as a Critical Hub Governing Mitochondrial Dysfunction and B Cell Differentiation in Periodontitis.Clinical, cosmetic and investigational dentistry · 2025Article
- A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis.Nature immunology · 2025Article
- Post-translational control of B lineage commitment.Nature immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Andres Gamez-GarciaChromatin Biology Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.ORCID http://orcid.org/0000-0003-4927-3678
Maria Espinosa-Alcantud *Chromatin Biology Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.
Alberto Bueno-Costa *Cancer Epigenetics Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.
Elisenda Alari-PahissaPompeu Fabra University, Barcelona, Spain.ORCID http://orcid.org/0000-0001-7424-5383
Anna Marazuela-DuqueChromatin Biology Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.
Joshua K ThackrayDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0003-2828-452X
Chandni RayDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.
Clara BerenguerEpigenetic Control of Hematopoiesis Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.
Poonam KumariDepartment of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Joan Josep BechProteomics Unit, Josep Carreras Leukemia Research Institute, Badalona, Spain.ORCID http://orcid.org/0000-0003-3486-781X
Thomas BraunDepartment of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID http://orcid.org/0000-0002-6165-4804
Alessandro IanniChromatin Biology Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.ORCID http://orcid.org/0000-0001-7398-589X
Jay A TischfieldDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.
Lourdes SerranoDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.
Manel EstellerCancer Epigenetics Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.
Jose L SardinaEpigenetic Control of Hematopoiesis Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain.ORCID http://orcid.org/0000-0002-8493-3937
Carolina De La TorreProteomics Unit, Josep Carreras Leukemia Research Institute, Badalona, Spain.
Mikael SigvardssonDivision of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, Lund, Sweden.
Berta N VazquezChromatin Biology Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain. bvazquez@carrerasresearch.org.ORCID http://orcid.org/0000-0002-8164-3926
Alejandro VaqueroChromatin Biology Laboratory, Josep Carreras Leukemia Research Institute, Badalona, Spain. avaquero@carrerasresearch.org.ORCID http://orcid.org/0000-0002-8735-4156
Funding
Barncancerfonden (Swedish Childhood Cancer Foundation) 2022-0019Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya (Department of Innovation, Education and Enterprise, Government of Catalonia) 2016-BP-00250Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya (Department of Innovation, Education and Enterprise, Government of Catalonia) 2017-SGR-148Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya (Department of Innovation, Education and Enterprise, Government of Catalonia) 2021-SGR-01378Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya (Department of Innovation, Education and Enterprise, Government of Catalonia) 2021-SGR-01494Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya (Department of Innovation, Education and Enterprise, Government of Catalonia) FI_B 00293EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) MSC-2020-895979EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) MSC-2021-101065013Forskningsrådet om Hälsa, Arbetsliv och Välfärd (Swedish Research Council for Health, Working Life and Welfare) 2021-02379Fundación Científica Asociación Española Contra el Cáncer (Scientific Foundation, Spanish Association Against Cancer) PROYE20042VAQUMinistry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) SAF2017-88975R
Abstract
B lymphopoiesis is orchestrated by lineage-specific transcription factors. In B cell progenitors, lineage commitment is mediated by Pax5, which is commonly mutated in B cell acute lymphoblastic leukemia. Despite its essential role in immunity, the mechanisms regulating Pax5 function remain largely unknown. Here, we found that the NAD
Indexed as
B-LymphocytesCell DifferentiationCell LineageLymphopoiesisPAX5 Transcription FactorSirtuinsAcetylationAnimalsHumansMiceMice, Inbred C57BLMice, KnockoutPAX5 protein, humanPax5 protein, mousePAX5 Transcription FactorSIRT7 protein, humanSirt7 protein, mouseSirtuins
Identifiers
What Socratic holds
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LicenceCC BY
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.