Evidence map›Paper›PMID 39425033›Full record

ArticleBMC molecular and cell biology2024

Induction of chronic asthma up regulated the transcription of senile factors in male rats.

Majid Hassanzadeh-Khanmiri, Rana Keyhanmanesh, Reza Mosaddeghi-Heris, Aref Delkhosh, Jafar Rezaie, Sajjad Taghizadeh, Mehdi Rezai Seghin Sara, Mahdi Ahmadi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC molecular and cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Majid Hassanzadeh-KhanmiriTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rana KeyhanmaneshDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza Mosaddeghi-HerisNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Aref DelkhoshDepartment of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Jafar RezaieSolid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Sajjad TaghizadehStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Mehdi Rezai Seghin SaraStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahdi AhmadiTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. mahdi59866@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe main characteristic of asthma is chronic inflammation. We examined cellular senescence by histology and molecular assay in the lungs of a rat model of asthma. This model comprises sensitization by several intraperitoneal injections of ovalbumin with aluminium hydroxide, followed by aerosol challenges every other day.

resultsData showed that asthma induction caused histological changes including, hyperemia, interstitial pneumonia, fibrinogen clots, and accumulation of inflammatory cells in the pleura. There is an elevation of IL-1β and NF-kB proteins in the asthmatic group (P < 0.001) compared to the control group. The expression of ß-galactosidase increased (P < 0.01), while the expression of Klotho and Sox2 genes was decreased in the lung tissue of the asthmatic group (P < 0.01).

conclusionTaken together, these findings suggest that asthmatic conditions accelerated the cellular senescence in the lung tissue.

Indexed as

AsthmaCellular SenescenceGlucuronidaseLungAnimalsbeta-GalactosidaseChronic DiseaseDisease Models, AnimalInterleukin-1betaMaleNF-kappa BOvalbuminRatsSOXB1 Transcription FactorsTranscription, GeneticUp-Regulationbeta-GalactosidaseGlucuronidaseInterleukin-1betaNF-kappa BOvalbuminSOXB1 Transcription FactorsAsthmaCellular senescenceInflammationß-galactosidase

Identifiers

PMID39425033
PMCPMC11492212

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.