Evidence map›Paper›PMID 39425510›Full record

ArticlePhysiological reports2024

Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice.

Jian-Xiong Chen, Jin Zhang, Yingjie Chen, Heng Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jian-Xiong ChenDepartment of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID 0000-0001-9203-4336
Jin ZhangDepartment of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Yingjie ChenDepartment of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Heng ZengDepartment of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID 0000-0001-8559-2807

Funding

Endothelial PHD2 in hypertensive vascular remodelingR01HL151536 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, JIAN-XIONG · 2021 to 2024
$1.6M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL151536University of Mississippi Medical Center
6 · The paper itself

Abstract

Sirtuin 3 has been shown to regulate endothelial function and coronary flow reserve in mice. Knockout of SIRT3 reduced endothelial nitric oxide synthase expression in the mouse hearts. In this study, we investigate whether endothelial SIRT3 regulates vascular function and myogenic responses in distal intramural branches of the left anterior descending coronary artery (CA) and middle cerebral artery (MCA) of mice. Both male and female endothelial SIRT3 knockout (SIRT3

Indexed as

Sirtuin 3VasodilationAcetylcholineAnimalsCoronary VesselsEndothelial CellsEndothelium, VascularFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMiddle Cerebral ArteryMuscle, Smooth, VascularAcetylcholineSirt3 protein, mouseSirtuin 3coronary arterioles (CA)EC‐dependent relaxation (EDR)EC‐independent relaxation (EIR)endothelial cell (EC)middle cerebral artery (MCA)myogenic responsesirtuin 3 (SIRT3)

Identifiers

PMID39425510
PMCPMC11489619

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.