Evidence map›Paper›PMID 39426039›Full record

ArticlePsychoneuroendocrinology2025

Exposure to diesel-related particulate matter, cortisol stress responsivity, and depressive symptoms in adolescents.

Jessica P Uy, Katy Shin, Jessica L Buthmann, Katharina Kircanski, Joelle LeMoult, Anne E Berens, Ian H Gotlib

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica P UyDepartment of Psychology, Stanford University, Stanford, CA, USA. Electronic address: jpuy@stanford.edu.
Katy ShinDepartment of Psychology, Stanford University, Stanford, CA, USA.
Jessica L ButhmannDepartment of Psychology, Stanford University, Stanford, CA, USA.
Katharina KircanskiEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.
Joelle LeMoultDepartment of Psychology, University of British Columbia, Vancouver, BC, Canada.
Anne E BerensDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA, USA.

Funding

Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6M
Effects of Early Life Stress and Sleep Disturbance on Frontolimbic Development and Risk for Depression Across AdolescenceF32MH135657 · NIMH · STANFORD UNIVERSITY · PI UY, JESSICA PHUONG · 2023 to 2025
$242k
NIMH NIH HHS F32 MH135657NIMH NIH HHS R37 MH101495
6 · The paper itself

Abstract

Exposure to air pollution is associated with higher risk for psychopathology; however, the mechanisms underlying this association are not clear. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress has been implicated in depression. Here, we estimated annual exposure to particulate matter (PM) from diesel emissions in 170 9- to 15-year-old adolescents (56 % female) using their residential addresses and data from nearby monitoring sites. We obtained salivary cortisol samples from participants while they completed a social stress task and calculated area under the curve with respect to ground (AUCg) and with respect to increase (AUCi) in order to assess cortisol responsivity during stress. Participants also reported on their depressive symptoms and sleep disturbances. Greater exposure to diesel PM was associated with lower cortisol output (AUCg) during stress, which was associated with higher depressive symptoms, particularly for adolescents with more sleep disturbances. Importantly, these effects were independent of household and neighborhood socioeconomic disadvantage and exposure to early adversity. Thus, HPA-axis dysfunction may be one mechanism through which environmental pollutants affect adolescents' mental health.

Indexed as

Air PollutantsDepressionHydrocortisoneHypothalamo-Hypophyseal SystemParticulate MatterPituitary-Adrenal SystemSalivaStress, PsychologicalVehicle EmissionsAdolescentAir PollutionChildEnvironmental ExposureFemaleHumansMaleAir PollutantsHydrocortisoneParticulate MatterVehicle EmissionsAdolescentsCortisolDepressionPollutionStress reactivity

Identifiers

PMID39426039
PMCPMC11568899

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.