ArticleJournal of psychosomatic research2024
The psychosocial anti-inflammatories: Sense of control, purpose in life, and social support in relation to inflammation, functional health and chronic conditions in adulthood.
Article in Journal of psychosomatic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Purpose in life and c-reactive protein: An individual-participant meta-analysis of >50,000 adults.Psychoneuroendocrinology · 2025Pooled it
- Life Sustaining Well-Being Practices and Physiological Health Among Black Men.Journal of racial and ethnic health disparities · 2026Article
- eHealth Literacy, self-management, and selected clinical and social correlates of nutrition-inflammation level among older adults with diabetes.BMC health services research · 2026Article
- Association between Japanese balanced diet and frailty: the modifying effects of social connections in Japanese older adults.BMC geriatrics · 2026Article
- Maintaining cognitive and physical health across the adult lifespan: the contribution of psychosocial factors.Journal of behavioral medicine · 2025Article
- Racial/Ethnic variation in health insurance coverage and early midlife depressive symptoms in the U.S.BMC health services research · 2025Article
- Relationship Between Family Support, C-Reactive Protein and Body Mass Index Among Outpatients with Schizophrenia.Healthcare (Basel, Switzerland) · 2025Article
- The role of purpose in life in healthy aging: implications for the Semmelweis Study and the Semmelweis-EUniWell Workplace Health Promotion Model Program.GeroScience · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectiveThree psychosocial variables were examined as predictors of chronic inflammation, functional health, and number of chronic conditions.
methodsThis cohort study used the Midlife in the United States biomarker sample. Data were collected in 2004-2009 (M2) and 2013-17 (M3). The sample included 1244 adults ages 34 to 82 (M = 54.50, SD = 11.7), with 57 % women, 79 % white, and education from 6 to 20 years (M = 14.47, SD = 2.65). Sense of control, purpose in life, and social support were included as indicators of a psychosocial latent factor. Inflammation was measured with Interleukin-6, C-reactive Protein, E-Selectin, Fibrinogen, and Intracellular Adhesion Molecule-1. Covariates included age, sex, education, race, and household income. Functional health and chronic conditions were assessed M = 9.27 (SD = 0.78) years after the psychosocial variables and M = 7.06, (SD = 1.47) years after inflammation.
resultsUsing a structural equation model and controlling for covariates, higher levels on the psychosocial variables predicted lower inflammation (β = -0.12, 95 % CI -0.22 to -0.02; p = .016), better functional health (β = 0.25, 95 % CI 0.18 to 0.32; p < .001), and fewer chronic conditions (β = -0.22, 95 % CI -0.30 to -0.15; p < .001), with inflammation a mediator (indirect effects: functional health, β = 0.03, 95 % CI 0.00 to 0.05, p = .020 and chronic conditions, β = -0.02, 95 % CI -0.03 to -0.00, p = .036).
conclusionsAdaptive psychosocial beliefs and supportive relationships are important as they can provide motivation for engaging in health-promoting behaviors and can reduce stress that can lead to chronic inflammation and poor health. The results can inform a psychosocial prescription for health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.