Evidence map›Paper›PMID 39427577›Full record

ArticlePsychiatry research2024

White matter correlates of dissociation in a diverse sample of trauma-exposed women.

Alexa Kondas, Timothy J McDermott, Vishwadeep Ahluwalia, Olivia C Haller, Maya C Karkare, Alfonsina Guelfo, Alexandra Daube, Bekh Bradley, Abigail Powers, Jennifer S Stevens and 3 more

Abstract read
In one paragraph

Article in Psychiatry research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexa KondasDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA.
Timothy J McDermottDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA.
Vishwadeep AhluwaliaGeorgia Institute of Technology, Atlanta, GA, USA; GSU/GT Center for Advanced Brain Imaging, Atlanta, GA, USA.
Olivia C HallerGeorgia State University, Atlanta, GA, USA.
Maya C KarkareDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA.
Alfonsina GuelfoDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA.
Alexandra DaubeDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA.
Bekh BradleyDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA.
Abigail PowersDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA.
Kerry J ResslerDivision of Depression and Anxiety, McLean Hospital, USA; Department of Psychiatry, Harvard Medical School, USA.
Greg J SiegleUniversity of Pittsburgh, Pittsburgh, PA, USA.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA. Electronic address: nfani@emory.edu.

Funding

Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Neural Mechanisms of Vibroacoustically Augmented Breath Focused Mindfulness for Dissociative Traumatized PeopleR01AT011267 · NCCIH · EMORY UNIVERSITY · PI FANI, NEGAR, SIEGLE, GREG J · 2021 to 2025
$4.1M
Neurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD SymptomsR01MH129832 · NIMH · DUKE UNIVERSITY · PI MOREY, RAJENDRA A, SCHMAAL, LIANNE · 2022 to 2025
$2.3M
Mechanisms of Intergenerational Impact of Maternal TraumaR01HD071982 · NICHD · EMORY UNIVERSITY · PI BRADLEY, BEKH · 2013 to 2017
$2.1M
Neural Mechanisms of Cognitive Control in Posttraumatic Stress DisorderK23MH101380 · NIMH · EMORY UNIVERSITY · PI FANI, NEGAR · 2014 to 2017
$601k
Neurophysiological mechanisms of anhedonia and cognitive control deficits in trauma-exposed people completing vibroacoustically augmented breath focused mindfulnessF32MH134631 · NIMH · EMORY UNIVERSITY · PI MCDERMOTT, TIMOTHY · 2023 to 2024
$143k
Neuroendophenotypes and Risk for Posttraumatic Stress DisorderF32MH095456 · NIMH · EMORY UNIVERSITY · PI FANI, NEGAR · 2011 to 2012
$101k
NCCIH NIH HHS R01 AT011267NICHD NIH HHS R01 HD071982NIMH NIH HHS F32 MH095456NIMH NIH HHS F32 MH134631NIMH NIH HHS K23 MH101380NIMH NIH HHS L30 MH101735NIMH NIH HHS L30 MH137711NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH129832
6 · The paper itself

Abstract

Dissociation is a common response to trauma linked to functional brain disruptions in brain networks subserving emotion regulation and multisensory integration; however, structural neural correlates of dissociation are less known, particularly abnormalities in stress-sensitive white matter (WM) tracts. The present study examined associations between dissociation and WM microstructure, assessed via fractional anisotropy (FA), in a large, diverse sample of women recruited as part of a long-standing trauma study, the Grady Trauma Project (GTP). As part of GTP, 135 trauma-exposed women (18-62 years old, M=34.25, SD=12.96, 84% self-identifying as Black) were recruited, received diffusion tensor imaging, and completed the Multiscale Dissociation Inventory (MDI); FA values were extracted from ten major WM tracts of interest. Partial correlations were conducted to examine associations between dissociation facets (MDI total and subscales) and FA while covarying age and temporal signal-to-noise ratio; false discovery rate corrected p < 0.05 indicated statistical significance. FA in seven tracts showed significant negative associations with overall dissociation (MDI total score; rs<-0.19, p

Indexed as

Diffusion Tensor ImagingDissociative DisordersWhite MatterAdolescentAdultAnisotropyBrainFemaleHumansMiddle AgedPsychological TraumaStress Disorders, Post-TraumaticYoung AdultDepersonalizationDerealizationDiffusion tensor imagingDissociationFractional anisotropyMemoryPTSD

Identifiers

PMID39427577
PMCPMC12105530

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.