Evidence map›Paper›PMID 39428713›Full record

ArticlePsychophysiology2025

Acute transcutaneous auricular vagus nerve stimulation modulates presynaptic SV2A density in healthy rat brain: An in vivo microPET study.

Karina H Binda, Caroline C Real, Mette T Simonsen, Ebbe K Grove, Dirk Bender, Albert Gjedde, David J Brooks, Anne M Landau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karina H BindaTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Caroline C RealDepartment of Nuclear Medicine and PET, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Mette T SimonsenDepartment of Nuclear Medicine and PET, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Ebbe K GroveDepartment of Nuclear Medicine and PET, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Dirk BenderDepartment of Nuclear Medicine and PET, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Albert GjeddeTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
David J BrooksDepartment of Nuclear Medicine and PET, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Anne M LandauTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-7371-8713

Funding

Danmarks Frie ForskningsfondFabrikant Vilhelm Pedersen og Hustrus LegatFonden til Lægevidenskabens FremmeGraduate School of Health, Aarhus University
6 · The paper itself

Abstract

Vagus nerve stimulation (VNS) is the subject of exploration as an adjunct treatment for neurological disorders such as epilepsy, chronic migraine, pain, and depression. A non-invasive form of VNS is transcutaneous auricular VNS (taVNS). Combining animal models and positron emission tomography (PET) may lead to a better understanding of the elusive mechanisms of taVNS. We evaluated the acute effect of electrical stimulation of the left vagus nerve via the ear on brain synaptic vesicle glycoprotein 2A (SV2A) as a measure of presynaptic density and glucose metabolism in naïve rats. Female Sprague-Dawley rats were imaged with [

Indexed as

BrainMembrane GlycoproteinsNerve Tissue ProteinsPresynaptic TerminalsTranscutaneous Electric Nerve StimulationVagus Nerve StimulationAnimalsFemaleFluorodeoxyglucose F18Positron-Emission TomographyRatsRats, Sprague-DawleyFluorodeoxyglucose F18Membrane GlycoproteinsNerve Tissue ProteinsSv2a protein, rat[11C]UCB‐J, [18F]FDGglucose metabolismPETsynaptic vesicle glycoprotein 2A (SV2A)transcutaneous auricular vagus nerve stimulation

Identifiers

PMID39428713
PMCPMC11775880

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.