Evidence map›Paper›PMID 39429132›Full record

ArticleBasic & clinical pharmacology & toxicology2024

An extended substrate spectrum of the proton organic cation antiporter and relation to other cation transporters.

Cauzar Ali Khan, Nicolai Kirsch, Jürgen Brockmöller, Kyra-Elisa Maria Redeker

Abstract read
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cauzar Ali KhanInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August-University Göttingen, Germany.
Nicolai KirschInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August-University Göttingen, Germany.
Jürgen BrockmöllerInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August-University Göttingen, Germany.
Kyra-Elisa Maria RedekerInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August-University Göttingen, Germany.ORCID https://orcid.org/0009-0008-8442-9635

Funding

Deutsche Forschungsgemeinschaft 461080000University Medical Center, University of Göttingen
6 · The paper itself

Abstract

Most central nervous system (CNS) active drugs are organic cations, which need carrier proteins for efficient transfer through the blood-brain barrier (BBB). A genetically still unidentified proton organic cation (H

Indexed as

Blood-Brain BarrierOrganic Cation Transport ProteinsAnimalsAntidepressive AgentsAntiportersAntipsychotic AgentsBiological TransportHEK293 CellsHumansHydrogen-Ion ConcentrationOctamer Transcription Factor-1Organic Cation Transporter 2Organic Cation Transporter 3ProtonsSolute Carrier Family 22 Member 5SymportersAntidepressive AgentsAntiportersAntipsychotic AgentsOctamer Transcription Factor-1Organic Cation Transporter 2Organic Cation Transporter 3Organic Cation Transport ProteinsPOU2F1 protein, humanProtonsSLC22A2 protein, humanSLC22A4 protein, humanSLC22A5 protein, humanSolute Carrier Family 22 Member 5Symportersblood–brain barrierclinically relevant drugshCMEC/D3 cellsorganic cation transporterproton organic cation antiporter

Identifiers

PMID39429132
PMCPMC11617647

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.