Evidence map›Paper›PMID 39429196›Full record

ArticleCirculation2025

Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations.

Yang Yang, Xiuju Wu, Yan Zhao, Daoqin Zhang, Li Zhang, Xinjiang Cai, Jaden Ji, Zheng Jing, Kristina I Boström, Yucheng Yao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Targeted proteomic analysis identifies ACVRL1 as a marker of cerebral edema in aneurysmal subarachnoid hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang Yang *Division of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.
Xiuju Wu *Division of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.ORCID 0000-0002-7499-0137
Yan Zhao *Division of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.
Daoqin ZhangDepartment of Pediatrics, Stanford University, CA (D.Z.).
Li ZhangDivision of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.ORCID 0000-0003-2638-2919
Xinjiang CaiDivision of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.ORCID 0000-0001-8933-7133
Jaden JiDivision of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.
Zheng JingDivision of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.ORCID 0000-0001-6501-0742
Kristina I BoströmDivision of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.ORCID 0000-0002-7745-5025
Yucheng YaoDivision of Cardiology, David Geffen School of Medicine (Y. Yang, X.W., Y.Z., L.Z., X.C., J.J., Z.J., K.I.B., Y. Yao), University of California, Los Angeles.ORCID 0000-0003-0483-9180

Funding

Molecular Mechanisms of MGP; Role in AVMsR01HL081397 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2006 to 2025
$7.7M
BMP and Notch Crosstalk in Cerebral Arteriovenous MalformationsR01NS079353 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2012 to 2026
$5.3M
Switch of Osteogenesis in Vascular CalcificationR01HL139675 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2018 to 2026
$3.6M
Endothelial Regulation of Vascular CalcificationR01HL158053 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2022 to 2025
$2.2M
Erasing ill features of arterial endothelial cells in hereditary hemorrhagic telangiectasiaR01HL162643 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YAO, YUCHENG · 2022 to 2025
$1.6M
Regulation of Vascular Calcification by Adventitial Endothelial CellsK08HL168147 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xinjiang Cai · 2023 to 2026
$692k
NHLBI NIH HHS K08 HL168147NHLBI NIH HHS R01 HL081397NHLBI NIH HHS R01 HL139675NHLBI NIH HHS R01 HL158053NHLBI NIH HHS R01 HL162643NINDS NIH HHS R01 NS079353
6 · The paper itself

Abstract

backgroundArteriovenous malformations (AVMs) are characteristic of hereditary hemorrhagic telangiectasia. Loss-of-function mutations in the activin receptor-like kinase 1 (

methodsEndothelial-specific deletion of

resultsWe performed endothelial-specific deletion of

conclusionsTogether, our studies revealed the mechanistic underpinnings of ALK1 signaling in regulating the endothelial phenotype and provided possibilities for new therapeutic strategies in hemorrhagic telangiectasia type 2.

Indexed as

ArteriesArteriovenous MalformationsEndothelial CellsLymphatic VesselsTelangiectasia, Hereditary HemorrhagicActivin Receptors, Type IActivin Receptors, Type IIAnimalsDisease Models, AnimalHumansMiceMice, KnockoutSOXF Transcription FactorsActivin Receptors, Type IActivin Receptors, Type IIAcvrl1 protein, mouseSOXF Transcription Factorsarterial endothelial cellsarteriovenous malformationshereditary hemorrhagic telangiectasia 2

Identifiers

PMID39429196
PMCPMC11789604

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.