Evidence map›Paper›PMID 39430293›Full record

ReviewFrontiers in molecular neuroscience2024

Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli.

Youngjae Ryu, Aboubacar Wague, Xuhui Liu, Brian T Feeley, Adam R Ferguson, Kazuhito Morioka

Abstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Advances in electrical stimulation for wound healing.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Youngjae RyuDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Aboubacar WagueDepartment of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States.
Xuhui LiuDepartment of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States.
Brian T FeeleyDepartment of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States.
Adam R FergusonDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Kazuhito MoriokaDepartment of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United States.

Funding

Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1M
NIAMS NIH HHS P30 AR075055
6 · The paper itself

Abstract

Mechanical stimuli, such as stretch, shear stress, or compression, activate a range of biomolecular responses through cellular mechanotransduction. In the nervous system, studies on mechanical stress have highlighted key pathophysiological mechanisms underlying traumatic injury and neurodegenerative diseases. However, the biomolecular pathways triggered by mechanical stimuli in the nervous system has not been fully explored, especially compared to other body systems. This gap in knowledge may be due to the wide variety of methods and definitions used in research. Additionally, as mechanical stimulation techniques such as ultrasound and electromagnetic stimulation are increasingly utilized in psychological and neurorehabilitation treatments, it is vital to understand the underlying biological mechanisms in order to develop accurate pathophysiological models and enhance therapeutic interventions. This review aims to summarize the cellular signaling pathways activated by various mechanical and electromagnetic stimuli with a particular focus on the mammalian nervous system. Furthermore, we briefly discuss potential cellular mechanosensors involved in these processes.

Indexed as

cellular signalingmechanical stressmechanosensormechanotransductionnervous system

Identifiers

PMID39430293
PMCPMC11486767

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.